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Locoregional Recurrence of Breast Cancer and Its Predictive Factors



Babazadeh S1 ; Amouheidari AR2 ; Tabatabaeian M3 ; Andalib AR4 ; Rezaei P5 ; Faghihi M6 ; Hajahmadian H1 ; Emami H7 ; Roayaei M7 ; Mokarian F8 ; Alamsamimi M9 ; Adibi A10 ; Hassanzadeh A11 ; Tazhibi M12 Show All Authors
Authors
  1. Babazadeh S1
  2. Amouheidari AR2
  3. Tabatabaeian M3
  4. Andalib AR4
  5. Rezaei P5
  6. Faghihi M6
  7. Hajahmadian H1
  8. Emami H7
  9. Roayaei M7
  10. Mokarian F8
  11. Alamsamimi M9
  12. Adibi A10
  13. Hassanzadeh A11
  14. Tazhibi M12
  15. Moazam E13
Show Affiliations
Authors Affiliations
  1. 1. Radiotherapist and Oncologist, Seyed-Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Radiotherapist and Oncologist, Milad Hospital, Isfahan, Iran
  3. 3. Seyed-Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Seyed-Al-Shohada Hospital, Isfahan, Iran
  6. 6. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Radiotherapy and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Hematologist and Oncologist, Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Department of Health Education and Promotion, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  13. 13. Specialist in Community Medicine, Seyed-Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: The aim of this study was to determine the incidence rate and predictors of locoregional recurrence (LRR) of breast cancer in women. Methods: A total number of 4652 records of women with breast cancer who had been treated in Seyed-Al-Shohada Hospital (Isfahan, Iran) during 1982-2006 were investigated retrospectively. Prognostic impact of several factors on LRR was assessed by log-rank test and logistic regression analysis. Findings: During the follow-up period with median length of 11 years, 208 patients (4.5%) had experienced LRR. The median time of LRR was two years. In univariate analysis test, tumor size, existence of progesterone receptors, severity of lymph node involvements, and young age had relations with LRR. Multivariate analysis revealed LRR to be significantly related with lymph nodes involvement and young age. Conclusion: LRR was not common among women with breast cancer in Isfahan Province. However, some subgroups of patients with specific risk factors such as younger age, large tumors, and more involved lymph nodes may be at greater risk of developing malignancy.
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