Simultaneous Detection of Morphine and Codeine in Urine Samples of Heroin Addicts Using Multi-Walled Carbon Nanotubes Modified Sno 2 -Zn 2 Sno 4 Nanocomposites Paste Electrode Publisher



Taei M¹ ; Hasanpour F¹ ; Hajhashemi V² ; Movahedi M¹ ; Baghlani H¹ Show Affiliations
Source: Applied Surface Science Published:2016

Abstract

The SnO 2 -Zn 2 SnO 4 nanocomposite was successfully prepared via a simple solid state method. Then, a chemically modified electrode based on incorporating SnO 2 -Zn 2 SnO 4 into multi-walled carbon nanotube paste matrix (MWCNTs/SnO 2 -Zn 2 SnO 4 /CPE) was prepared for the simultaneous determination of morphine(MO) and codeine (CO). The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry, and chronoamperometry. The MWCNTs/SnO 2 -Zn 2 SnO 4 /CPE showed an efficient electrocatalytic activity for the oxidation of MO and CO. The separation of the oxidation peak potential for MO-CO was about 550 mV. The calibration curves obtained for MO and CO were in the ranges of 0.1-310 μmol L -1 and 0.1-600.0 μmol L -1 , respectively. The detection limits (S/N = 3) were 0.009 μmol L -1 for both drugs. The method also successfully employed as a selective, simple, and precise method for the determination of MO and CO in pharmaceutical and biological samples. © 2015 Elsevier B.V. All rights reserved.