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Assessment of Effective Absorbed Dose of 111In-Dtpa-Buserelin in Human on the Basis of Biodistribution Rat Data Publisher Pubmed



Lahooti A1 ; Shanehsazzadeh S1 ; Jalilian AR2 ; Tavakoli MB3
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, 16 Azar Street, Iran
  2. 2. Radiopharmaceutical Research and Development Laboratory Nuclear Sciences and Technology, Research Institute, Tehran, Iran
  3. 3. Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Radiation Protection Dosimetry Published:2013


Abstract

In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of 111In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of 111In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats. ©The Author 2012. Published by Oxford University Press.
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