Comparison the Effects of Two Different Doses of Dexmedetomidine and Propofol on Intraoperative Sedation; Hemodynamic Changes and Postoperative Complications in Patients Undergoing Ovarian Puncture Surgery Publisher

Summary: A study shows dexmedetomidine outperforms propofol in ovarian surgery, offering better pain relief and satisfaction. #Anesthesia #Surgery

Mr Habibzadeh Mohammadreza REZA ; A Ghosouri ATEFEH ; Z Vazifeh Azadani ZAHRA ; Z Farajzadegan ZIBA
Source: Advanced Biomedical Research Published:2025

Abstract

Background: This study aimed to evaluate the effects of different doses of dexmedetomidine and propofol on sedation, hemodynamic changes, and postoperative complications in patients undergoing ovarian puncture surgery. Materials and Methods: This randomized controlled trial was conducted on 96 women candidates for ovarian puncture surgery. In the first group (DEX-0.5), a bolus dose of dexmedetomidine 0.5 μg/kg was administered for the induction of anesthesia, followed by a maintenance dose of dexmedetomidine 0.5 μg/kg/min. In the second group (DEX-1), a bolus dose of dexmedetomidine 1 μg/kg was administered for induction, followed by a maintenance dose of dexmedetomidine 1 μg/kg/min. In the third group (control group), propofol 50 μg/kg/min was administered for induction of anesthesia. Results: SBP, DBP, and MAP were significantly lower in the control group compared to the other groups (P value < 0.05). The mean scores of patient and surgical satisfaction levels in the DEX-0.5 group were significantly higher than the control group (4.00 ± 1.02 and 4.41 ± 0.57, respectively) and in the DEX-1 group (6.00 ± 1.35 and 4.61 ± 0.56, respectively) compared to the control group (2.90 ± 2.10 and 3.10 ± 0.32, respectively) (P value < 0.05). Need for additional analgesics was significantly higher in the control group compared to the intervention groups (P value < 0.05). Conclusion: It seems that the administration of dexmedetomidine 1 μg/kg, due to better pain relief, higher satisfaction, less need for additional analgesics, and minimal occurrence of complications, can be recommended as a safe and effective dose in ovarian puncture surgery. © 2025 Elsevier B.V., All rights reserved.