The Effects of Acute and Subacute Sodium Arsenite Administration on Carbohydrate Metabolism Publisher Pubmed



Ghafghazi T^{1, 2} ; Ridlington JW^{1, 2} ; Fowler BA^{1, 2} Show Affiliations
Source: Topics in Catalysis Published:1980

Abstract

The effects of acute and subacute trivalent arsenic (As) administration on blood glucose levels, glucose tolerance, and mitochrondrial respiration were studied in male rats injected with sodium arsenite at 0, 5, or 10 mg/kg body wt and killed after 1.5 or 3 hr or 7 days. Hyperglycemia and glucose intolerance were observed in rats which received single acute doses of As. Hyperglycemia, but not glucose intolerance, was found to be abolished, in As-treated adrenalectomized animals. No measureable changes in hepatic mitochondrial respiratory function were noted in animals killed at 1.5 or 3 hr following As administration. Animals injected with 10 mg As/kg for 7 days showed hyperglycemia and marked glucose intolerance at 24 hr after the last injection. Mild depression of pyruvate/malate mediated state 3 mitochondrial respiration and decreased respiratory control ratios were observed for hepatic mitochondria isolated from arsenite injected rats in comparison with controls at this time point. The findings of this study indicate that arsenical disturbance of in vivo carbohydrate metabolism is a complex phenomenon which involves a number of organ systems and their functional interrelationships. © 1980, All rights reserved.