Validity of the Adrogue-Madias Formula for the Management of Acute Dysnatremias in Critically Ill Children: A Prospective Multicenter Analysis Publisher Pubmed



Assadi F¹ ; Azarfar A² ; Bazargani B³ ; Derakhshan A⁴ ; Abassi A³ ; Mehrkash M⁵ ; Moghtaderi M³ ; Basiratnia M⁴ ; Mazaheri M⁶ ; Safaeiasl A⁷ ; Eskandarifar A⁸ ; Sharbaf FG² ; Badeli H⁷ ; Naghshizadian R⁸
Source: Pediatric Emergency Care Published:2023

Abstract

Validity of the Adrogue-Madias formula for the management of acute dysnatremias in critically ill children: a prospective multicenter analysis. Objective Current conventional formulas do not predict the expected changes in serum sodium after administration of various fluids to correct serum sodium abnormalities. The Adrogue-Madias formula is currently the preferred and widely used fluid prescription for adult patients with dysnatremias, but its therapeutic efficacy has not been validated in pediatric patients. Methods In this prospective study, we used the Adrogue-Madias formula for calculating the appropriate rate of various fluids administration to correct serum sodium abnormalities in 7 critically ill children with acute dysnatremias. Results After administration of various intravenous fluids using the Adrogue-Madias formula, the anticipated as well as the achieved sodium concentrations were almost similar. Conclusions This study demonstrates that the use of the Adrogue-Madias quantitative formula allows to calculate the appropriate rate of administration of various fluids. The calculated fluid administration resulted in the subsequent actual laboratory values and clinical changes. © Wolters Kluwer Health, Inc. All rights reserved.