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Validity of the Adrogue-Madias Formula for the Management of Acute Dysnatremias in Critically Ill Children: A Prospective Multicenter Analysis Publisher Pubmed



Assadi F1 ; Azarfar A2 ; Bazargani B3 ; Derakhshan A4 ; Abassi A3 ; Mehrkash M5 ; Moghtaderi M3 ; Basiratnia M4 ; Mazaheri M6 ; Safaeiasl A7 ; Eskandarifar A8 ; Sharbaf FG2 ; Badeli H7 ; Naghshizadian R8
Authors
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Authors Affiliations
  1. 1. Division of Nephrology, Department of Pediatrics, Rush University Medical Center, Chicago, IL, United States
  2. 2. Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Pediatric Chronic Kidney Disease Center, The Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Section of Nephrology, Department of Pediatrics, Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Section of Nephrology, Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Section of Nephrology, Department of Pediatrics, Semnan University of Medical Sciences, Semnan, Iran
  7. 7. Pediatric Kidney Diseases Research Center, Guilan University of Medical Science, Rasht, Iran
  8. 8. Section of Nephrology, Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Pediatric Emergency Care Published:2023


Abstract

Validity of the Adrogue-Madias formula for the management of acute dysnatremias in critically ill children: a prospective multicenter analysis. Objective Current conventional formulas do not predict the expected changes in serum sodium after administration of various fluids to correct serum sodium abnormalities. The Adrogue-Madias formula is currently the preferred and widely used fluid prescription for adult patients with dysnatremias, but its therapeutic efficacy has not been validated in pediatric patients. Methods In this prospective study, we used the Adrogue-Madias formula for calculating the appropriate rate of various fluids administration to correct serum sodium abnormalities in 7 critically ill children with acute dysnatremias. Results After administration of various intravenous fluids using the Adrogue-Madias formula, the anticipated as well as the achieved sodium concentrations were almost similar. Conclusions This study demonstrates that the use of the Adrogue-Madias quantitative formula allows to calculate the appropriate rate of administration of various fluids. The calculated fluid administration resulted in the subsequent actual laboratory values and clinical changes. © Wolters Kluwer Health, Inc. All rights reserved.
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