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Case Report: Can Fibrinolytics Effectively Manage Gross Hematuria and Clot Retention in an Elderly Patients, Leading to the Diagnosis of Lymphoma? Publisher



Bighamian M ; Jamadi MS ; Dorostkar A ; Rajaee Rizi F
Authors

Source: Urology Case Reports Published:2025


Abstract

A 77-year-old man presented with severe gross hematuria and extensive urinary tract clot retention unresponsive to catheterization and irrigation. CT showed clots throughout the upper and lower tracts; labs revealed pancytopenia and elevated creatinine. Bilateral nephrostomies with multiple Alteplase instillations dissolved clots, restored urinary flow, and normalized renal function. Bone marrow biopsy confirmed B-cell lymphoma. This case highlights fibrinolytic therapy as a minimally invasive option for clot retention and the importance of multidisciplinary evaluation in uncovering malignancies presenting with complex urologic emergencies. © 2025 Elsevier B.V., All rights reserved.