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The Effect of Extremely Low-Frequency Magnetic Fields on the Level of Serotonin Metabolite in the Raphe Nuclei of Adult Male Rat



Shahbazi D1, 5, 7 ; Shiri L2 ; Alaei H3 ; Naghdi N4 ; Kermani S1, 5, 7 ; Afrouzi H6 ; Kiani A1, 5, 7 ; Akbari M8
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biomedical Engineering, School of Medicine AND Student Research Committee\, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Department of Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Chemistry, School of Basic Sciences, Lorestan University, Khorramabad, Iran
  7. 7. Department of Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: According to several studies, the extremely low-frequency magnetic fields (ELF fields) affect extensively on biological system. These fields can influence the nervous and neurotransmitter system due to the electrical nature of them. The influences in some cases are therapeutic and sometimes are destructive. The purpose of this study was to investigate the effect of extremely low-frequency magnetic fields, with frequency of 10 Hz and intensity of 720 to 540 microtesla, on the level of serotonin metabolite, 5-Hydroxyindoleacetic Acid (5-HIAA), in the raphe nuclei of adult male rat. Methods: Using a magnetic coil, the extremely low-frequency magnetic field, with 690 microtesla strength at the center of the coil, was produced. 6 rats were under this field 3 hours daily for 15 consecutive days. Then, 6 samples were collected from the raphe nucleus of each rat using microdialysis technique. Each sample was 40 microliters in volume. Then, the serotonin metabolite levels in each sample were measured via high-pressure liquid chromatography and compared with its control sample. Findings: Extremely low-frequency magnetic field with mentioned characteristics significantly decreased the level of serotonin metabolite in the raphe nucleus compared to the control group (P < 0.05). Conclusion: It can be concluded that extremely low-frequency magnetic fields affect the serotonergic system and can be used to treat some diseases. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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