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Antiphospholipid Antibody Nephropathy; an Updated Mini-Review Publisher



Salesi M1 ; Ansari N2
Authors
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Authors Affiliations
  1. 1. Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Nephropathology Published:2025


Abstract

Antiphospholipid antibody nephropathy (APLN) is a rare autoimmune disease that affects the kidneys. It is characterized by the deposition of antiphospholipid antibodies (aPL) in the walls of small blood vessels in the kidneys. These antibodies cause inflammation and damage to the blood vessels, leading to various symptoms, including proteinuria, hematuria, hypertension, and renal failure. Several pathological lesions have been identified in APLN, including thrombotic microangiopathy, glomerular endothelial swelling, and fibrinoid necrosis of glomerular capillaries. Thrombotic microangiopathy is the most common lesion and is characterized by the formation of small blood clots in the vessels of the kidney, which can lead to kidney damage and dysfunction. In addition to these lesions, APLN can also cause damage to the tubules and interstitium of the kidney, leading to tubular atrophy, interstitial fibrosis, and chronic kidney disease. These lesions are thought to be caused by the chronic inflammation and immune response associated with APLN. © 2025 The Author(s).
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