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Oxford-Mest Classification in Iga Nephropathy Patients: A Report From Iran Publisher



Nasri H1 ; Mortazavi M2 ; Ghorbani A3 ; Shahbazian H3 ; Kheiri S4 ; Baradaran A5 ; Emaminaieni A2 ; Saffari M1 ; Mardani S6 ; Momeni A6 ; Madihi Y2 ; Baradaranghahfarokhi M7 ; Rafieiankopaie M8 ; Hedayati P2 Show All Authors
Authors
  1. Nasri H1
  2. Mortazavi M2
  3. Ghorbani A3
  4. Shahbazian H3
  5. Kheiri S4
  6. Baradaran A5
  7. Emaminaieni A2
  8. Saffari M1
  9. Mardani S6
  10. Momeni A6
  11. Madihi Y2
  12. Baradaranghahfarokhi M7
  13. Rafieiankopaie M8
  14. Hedayati P2
  15. Baradaran S9
  16. Ardalan M10
  17. Sajjadieh S2
  18. Assarzadegan N11
  19. Ahmadi Soleimani SM12
  20. Tamadon MR13
Show Affiliations
Authors Affiliations
  1. 1. Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Nephrology, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Biostatistics and Epidemiology, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Medical Physics and Medical Engineering Department, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  9. 9. Division of Renal Immunopathology, Dr. Baradaran Laboratory, Isfahan, Iran
  10. 10. Department of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran
  11. 11. Cardiovascular and Renal Research Laboratory, Memorial University of New found land, Canada
  12. 12. Department of Physiology, Tarbiat Modares University, Tehran, Iran
  13. 13. Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran

Source: Journal of Nephropathology Published:2012


Abstract

Background: There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region. Objectives: The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory. Patients and Methods: At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system. Results: In this survey, of 102 patients 71.6% were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2%, E: 32%, S: 67% also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females. Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001). Conclusions: Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease. In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system. © 2012, Society of Diabetic Nephropathy Prevention. All rights reserved.
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