Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Interplay Between Fasting, Gut Microbiota, and Lipid Profile Publisher Pubmed



Mohammadzadeh A1 ; Roshanravan N2 ; Mesri Alamdari N3 ; Safaiyan A4 ; Mosharkesh E5 ; Hadi A6 ; Barati M7 ; Ostadrahimi A8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Road Traffic Centre, Department of Biostatistics and Epidemiology, Tabriz Medical Science University, Tabriz, Iran
  5. 5. Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
  6. 6. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Journal of Clinical Practice Published:2021


Abstract

Background: This study aimed to investigate the consequence of Ramadan fasting on gut bacterium (Bacteroides and Firmicutes), serum concentration for butyrate, and lipid profile. Methods: Thirty healthy subjects were enlisted and investigated two times (before and at the end of Ramadan). Fasting blood samples were obtained for measuring fasting blood sugar (FBS) and lipid profile and serum butyrate concentration. Anthropometrics variables were measured before and after Ramadan for all 30 subjects. Quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis, targeting the genome of Bacteroides and Firmicutes was performed to determine its presence in the stool samples. Food intake was assessed by a 3-day food record before and after Ramadan. Statistical analysis was performed by SPSS ver.13 and Minitab ver.17. P < 0.05 considered the level of significance. Results: The study results showed that serum levels of butyrate significantly increase during the month from 0.23 ± 0.02 mM to 0.46 ± 0.03 mM (P < 0.05). The gut Bacteroides and Firmicutes increased by 21 and 13 percent after Ramadan compared to before (P < 0.05). The increment in Bacteroides occurred in both sexes, but Firmicutes significantly increased only in women. Food intake was decreased during Ramadan. Ramadan fasting caused significant reduction in BMI from 25.72 ± 0.58 kg/m2to 25.25 ± 0.55 kg/m2 (P < 0.05). Serum levels of LDL, HDL, LDL/HDL ratio, and total cholesterol significantly decreased during Ramadan (P < 0.05). However, the decrease in FBS and TG level were not statistically significant (P > 0.05). Conclusion: It can be stated that the promotion of Bacteroides and Firmicutes in the gut might play a crucial role in health promotion. However, more research is needed to achieve a definite conclusion. © 2021 John Wiley & Sons Ltd
Related Docs
View other Related Docs
1. The Effect of Fasting in Ramadan on the Values and Interrelations Between Biochemical, Coagulation and Hematological Factors, Annals of Saudi Medicine (2000)
2. Is Ramadan Fasting Related to Health Outcomes? a Review on the Related Evidence, Journal of Research in Medical Sciences (2014)
3. Effects of Ramadan Fasting on Acute Upper Gastrointestinal Bleeding Due to Peptic Ulcer, Journal of Research in Medical Sciences (2006)
4. Ramadan Fasting and Digestive Disorders: Sepahan Systematic Review No. 7, Journal of Research in Medical Sciences (2012)
5. Effects of Ramadan Fasting on Glucose Homeostasis, Lipid Profiles, Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome in Kashan, Iran, Archives of Iranian Medicine (2015)
6. Ramadan Fasting and Risk of Covid-19, International Journal of Preventive Medicine (2020)
7. The Effects of Probiotics on Body Weight and Biomarkers of Animal, Pakistan Journal of Nutrition (2013)
8. Effect of Honey Vinegar Syrup on Blood Sugar and Lipid Profile in Healthy Subjects, International Journal of Preventive Medicine (2014)
Experts (# of related papers)
View all Related Experts
Awat Feizi (3)
Nizal Sarrafzadegan (2)
Other Related Docs
9. Consumption of Sugar-Sweetened Beverages in Relation to the Metabolic Syndrome Among Iranian Adults, Obesity Facts (2012)
10. Association Between Ultra-Processed Foods Intake With Lipid Profile: A Cross-Sectional Study, Scientific Reports (2023)
11. Evaluation of Self-Perceived Changes in Gastrointestinal Symptoms During Ramadan Fasting, Journal of Religion and Health (2017)
12. A Review of the Effect of Synbiotic Foods on Reducing and Treating Constipation in Fasted People During the Month of Ramadan, Journal of Nutrition and Food Security (2024)
13. Recommendations for Ramadan Fasting in Patients With Diabetes Mellitus Based on Integrative Medicine and According to the Persian Culture-A Review Study, Journal of Isfahan Medical School (2023)
14. Ramadan Fasting and Inflammatory Bowel Disease, Indian Journal of Gastroenterology (2008)
15. International Survey on Complications of Religious Fasting After Metabolic and Bariatric Surgery, Scientific Reports (2023)
16. The Effects of 6 Mo of Supplementation With Probiotics and Synbiotics on Gut Microbiota in the Adults With Prediabetes: A Double Blind Randomized Clinical Trial, Nutrition (2020)