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Evaluation of Il-17 Gene Expression in the Peripheral Blood of Patients With Common Variable Immunodeficiency



Yazdani R1 ; Hakemi MG2, 4 ; Sherkat R3 ; Masjedi M2, 4 ; Zarkesh H2, 4 ; Hosseini M5
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Producing IL-17, Th17 cells induce BAFF and APRIL, two important mediators for Bcell survival and activation. Common variable immunodeficiency (CVID) is a group of many primary immunodeficiency diseases with a common set of features (including hypo-gammaglobulinemia) and different underlying causes. The prevalence of CVID is 1 to 50,000. Hence, the aim of this study was to measure IL-17 gene expression in peripheral blood of patients with CVID. Methods: Total mRNA extracted from whole blood samples of 10 patients with CVID and 10 normal controls; then, IL-17 gene was measured using qRT-PCR. Findings: There was a slight decrease in transcript levels of IL-17 in patients with CVID, even though, it was not statistically significant (P = 0.195). Conclusion: We showed that IL-17 is decreased in patients with CVID and this could be an explanation for their humoral immunity response insufficiencies. Absence of statistical significance in this IL-17 reduction may be due to our sample size and increasing the number of samples may result in statistical significance of this in future studies.
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