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Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights Into Its Regulatory Mechanisms Publisher Pubmed



Dadgostar E1, 2 ; Fallah M3 ; Izadfar F4 ; Heidarisoureshjani R5 ; Aschner M6 ; Tamtaji OR5 ; Mirzaei H7
Authors
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Authors Affiliations
  1. 1. Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  5. 5. Students' Scientific Research Center, Tehran University of medical sciences, Tehran, Iran
  6. 6. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  7. 7. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Mini-Reviews in Medicinal Chemistry Published:2021


Abstract

Glioma is a prevalent primary tumor of the brain and spinal cord. Several biological path¬ways play an important role in the pathogenesis of glioma, including apoptosis, autophagy, cell cycle arrest, migration, and invasion. The low efficacy of chemotherapy and radiation therapy has forced researchers to evaluate alternative treatments for glioma. In this regard, flavonoids have been studied. Resveratrol is a flavonoid with distinct pharmacological activities that has been used in the treatment of various diseases. Several recent studies have also focused on its therapeutic efficacy against glio¬ma. Resveratrol exerts its pharmacological attributes by regulating various molecular and cellular pathways. Here, we review contemporary knowledge in support of the use of resveratrol in the treat¬ment of glioma and its effects on various molecular and cellular mechanisms. © 2021 Bentham Science Publishers.
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