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Hepatitis D Virus Infection in Isfahan, Central Iran: Prevalence and Risk Factors Among Chronic Hbv Infection Cases



Ataei B2 ; Yazdani MR2 ; Kalantari H1 ; Yaran M2 ; Nokhodian Z2 ; Javadi AA2 ; Babak A3 ; Adibi P1
Authors
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Authors Affiliations
  1. 1. Isfahan Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Hepatitis Monthly Published:2011

Abstract

Background: Hepatitis D virus (HDV) is dependent on hepatitis B virus (HBV) infection. Acute infection with HDV can occur simultaneously with acute HBV infection or be superimposed onto a chronic HBV infection. Objectives: This study aimed to identify cases of HDV and determine its prevalence in patients with chronic HBV infection for the first time study in Isfahan, central Iran. Patients and Methods: In a cross-sectional study in 2009, 346 who had been diagnosed for at least 6 months with chronic HBV were enrolled consecutively. Anti-HDV was measured by ELISA in the serum of these patients. Results: The study included 245 males (70.8%) and 101 (29.2%) females with a mean age of 39 ± 12.4 years. Anti-HDV was present in 8 (3.5%) HBe antibody-positive patients (p = 0.36) and in 2 (2.3%) HBe antigen-positive cases (p = 0.68). No association was found between hepatitis D and probable risk factors. Conclusions: This study demonstrates that the prevalence of HDV infection is higher in patients who are positive for HBeAb compared those who are HBeAg-positive. Therefore, most HDV antibody-positive cases in Isfahan are HBV/HDV super infections but not co infections. © 2011 Kowsar M.P.Co. All rights reserved.
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