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An Efficient Deep Eutectic Magnetic Nano Gel for Rapid Ultrasound-Assisted Dispersive Μ-Solid Phase Extraction of Residue of Tetracyclines in Food Samples Publisher



Shirani M1 ; Faraji M2 ; Rashidi Nodeh H3 ; Akbariadergani B4 ; Sepahi S5
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Science, University of Jiroft, P. O. Box 7867161167, Jiroft, Iran
  2. 2. Research Group of Food, Halal and Agricultural Products, Research Department of Food Technology and Agricultural Products, Standard Research Institute (SRI), P.O. Box 31745-139, Karaj, Iran
  3. 3. Department of Food Science and Technology, Faculty of Food Industry and Agriculture, Standard Research Institute, Karaj, Iran
  4. 4. Food and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
  5. 5. Laboratories of Food and Drug Control, Vice Chancellery for Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Food Science and Technology Published:2023


Abstract

In the present study, a magnetic nano gel as the sorbent which is the combination of octatonic acid: cumarin as eutectic solvent and Fe3O4@SiO2 was introduced as the sorbent in ultrasound-assisted dispersive µ-solid phase extraction process coupled with high performance liquid chromatography with photo diode array detector for simultaneous separation and determination of tetracyclines residues in food samples. FT-IR, SEM, VSM were used for the characterization of the synthetized magnetic nano gel. Under obtained optimum conditions, the obtained linear ranges were 1.5–500 (µg L−1), 2.5–750 (µg L−1), 2–750 (µg L−1), and 2.5–500 (µg L−1) for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. Moreover, the below level of quantification (BLQ) (based on S/N = 3) of 0.47 µg L−1, 0.11 µg L−1, 0.85 µg L−1, 0.66 µg L−1, 0.81 µg L−1 and the limit of quantification (based on S/N = 10) of 1.61, 2.74, 2.23 (µg L−1), and 2.66 were achieved for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. The intra-day and inter-day precision (%) of the procedure were less than 3.2 and 3.8, respectively. The recoveries over 95% confirmed high sufficiency of the proposed method for application in complex matrices such as honey, milk, and egg. Graphical abstract: [Figure not available: see fulltext.]. © 2023, Association of Food Scientists & Technologists (India).