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Metformin-Induced Generalized Bullous Fixed-Drug Eruption With a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review Publisher



Abtahinaeini B1, 2 ; Momen T3 ; Amiri R4 ; Rajabi P5 ; Rastegarnasab F6
Authors
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Authors Affiliations
  1. 1. Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Asthma, Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Case Reports in Dermatological Medicine Published:2023


Abstract

Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug reactions for proper diagnosis and treatment. Herein, we report a 43-year-old man with generalized bullous lesions with a positive dechallenge-rechallenge test diagnosed as metformin-induced generalized bullous fixed-drug eruption. Metformin dosage was stopped and lesions were treated with topical clobetasol propionate and oral prednisolone and cyclosporine-A. After a 6-month follow-up, he was well without any relapsing episodes. © 2023 Bahareh Abtahi-Naeini et al.
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