A Case of Wolfram Syndrome

A Case of Wolfram Syndrome

Naderian G¹ ; Ashtari F¹ ; Nourimahdavi K¹ ; Sajjadi V¹

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1. Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Ophthalmic and Vision Research Published:2010

Abstract

Purpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. Conclusion: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.

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3. Homozygosity Mapping and Direct Sequencing Identify a Novel Pathogenic Variant in the Cisd2 Gene in an Iranian Wolfram Syndrome Family, Acta Diabetologica (2020)

4. Ocular Manifestations in Hemodialysis Patients: Importance of Ophthalmic Examination in Prevention of Ocular Sequels, International Journal of Preventive Medicine (2019)

5. Urbach-Wiethe Syndrome and the Ophthalmologist: Review of the Literature and Introduction of the First Instance of Bilateral Uveitis, Case Reports in Medicine (2012)

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Style	Citing Format
MLA	Naderian G, et al.. "A Case of Wolfram Syndrome." Journal of Ophthalmic and Vision Research, vol. 5, no. 1, 2010, pp. 53-56.
APA	Naderian G, Ashtari F, Nourimahdavi K, Sajjadi V (2010). A Case of Wolfram Syndrome. Journal of Ophthalmic and Vision Research, 5(1), 53-56.
Chicago	Naderian G, Ashtari F, Nourimahdavi K, Sajjadi V. "A Case of Wolfram Syndrome." Journal of Ophthalmic and Vision Research 5, no. 1 (2010): 53-56.
Harvard	Naderian G et al. (2010) 'A Case of Wolfram Syndrome', Journal of Ophthalmic and Vision Research, 5(1), pp. 53-56.
Vancouver	Naderian G, Ashtari F, Nourimahdavi K, Sajjadi V. A Case of Wolfram Syndrome. Journal of Ophthalmic and Vision Research. 2010;5(1):53-56.
BibTex	@article{ author = {Naderian G and Ashtari F and Nourimahdavi K and Sajjadi V}, title = {A Case of Wolfram Syndrome}, journal = {Journal of Ophthalmic and Vision Research}, volume = {5}, number = {1}, pages = {53-56}, year = {2010} }
RIS	TY - JOUR AU - Naderian G AU - Ashtari F AU - Nourimahdavi K AU - Sajjadi V TI - A Case of Wolfram Syndrome JO - Journal of Ophthalmic and Vision Research VL - 5 IS - 1 SP - 53 EP - 56 PY - 2010 ER -

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