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Diabetic Retinopathy and Corneal Endothelial Parameters: An Analytical Cross-Sectional Study Publisher Pubmed



Mortazavi SAA1 ; Akhlaghi M1 ; Dehghani A1 ; Pourazizi M1 ; Malekahmadi M1 ; Fazel M1 ; Tavakoli M1 ; Noorshargh P1
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Authors Affiliations
  1. 1. Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: BMC Ophthalmology Published:2022


Abstract

Background: To investigate the possible association of different pattern of diabetic retinopathy (DR) on corneal endothelium cells in type 2 diabetes mellitus patients. Methods: In this descriptive-analytical cross-sectional study, corneal endothelium parameters including endothelial cell density (ECD), average cell size (AVG), coefficient of variation in cell size (CV), and hexagonality (Hex) were evaluated by non-contact specular microscopy. Results: One hundred and thirty-four eyes of 134 diabetic patients including 77 females (57.5%) with a mean age of 61.03 ± 8.08 years were enrolled. The overall corneal parameters in diabetic patients with and without retinopathy were not significantly different (P > 0.05). There is a significant relationship between CV and the duration of the disease with age variable control (B = 0.369, p-value < 0.001). Conclusions: Corneal endothelial parameters were not associated with DM in patients without and with DR. There is a significant relationship between CV and the duration of the disease with age variable control. © 2022, The Author(s).
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