Increased Β-Globulin Fractions of the Serum Proteins in Rabbit Experimental Autoimmune Myasthenia Gravis



Messripour M¹ ; Torabinia D¹
Source: Acta Cardiomiologica Published:1996

Abstract

Rabbit experimental autoimmune myasthenia gravis (EAMG) has been produced and the relationship of the pattern of serum protein electrophoresis, anti-AChR titers and clinical muscle weakness in individual animals were studied. The responses of the animals to the immunizations with rat leg muscle acetylcholine receptor (AChR) were significantly different. The muscle weakness did not correlate with the titer of anti-AChR antibody produced in the individual rabbits. However, during the course of immunizations, a relationship was seen between the onset of the animal muscle weakness and β-globulin fractions of the serum proteins as examined by electrophoresis. The data suggest that the concentration of the serum β- globulin may be taken as a clinical parameter to evaluate prognosis of myasthenia gravis.