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On the Bioactivity and Mechanical Properties of Gehlenite Nanobioceramic: A Comparative Study Publisher



Bigham A1 ; Kermani S2, 3 ; Saudi A4 ; Aghajanian AH5 ; Rafienia M6
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Advanced Materials Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Department of Bioelectrics and Biomedical Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Iran
  4. 4. Stud. Research Committee, School of Advanced Medical Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Materials Engineering, Faculty of Engineering, Razi University, Kermanshah, Iran
  6. 6. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Medical Signals and Sensors Published:2020


Abstract

Background: For a new biomaterial which is going to be applied in bone tissue regeneration, bioactivity (bone bonding ability) and desirable mechanical properties are very essential parameters to take into consideration. In the present study, the gehlenite's mechanical properties and bioactivity are assessed and compared with hydroxyapatite (HA) for bone tissue regeneration. Method: Gehlenite and HA nanoparticles are synthesized through sol-gel method and coprecipitation technique, respectively, and their physical and chemical properties are characterized through X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. Results: The results prove that the gehlenite and HA phases without any undesirable phase are obtained, and the particles of both compounds are in the nanometer range with spherical morphology. The compressive strength of both compounds are assessed, and the values for gehlenite and HA disks are 144 ± 5 and 150 ± 4.8 MPa, respectively. Next, their bioactivity potential is assessed into simulated body fluid (SBF) up to 21 days, and the results show that after 14 days, gehlenite disk's surface is completely covered with newly formed Ca-P particles. However, some sporadic precipitations after 21 days soaking into SBF are formed onto the HA disk's surface. Conclusion: This comparative study shows that nanostructured gehlenite disk with desirable mechanical properties and faster bioactivity kinetic than HA can be considered as a promising bioceramic for bone tissue regeneration. © 2020 Journal of Medical Signals & Sensors.
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