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The Role of the Spatially Fractionated Radiation Therapy in the Management of Advanced Bulky Tumors Publisher



Mahmoudi F1 ; Shahbazigahrouei D1 ; Chegeni N2
Authors
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Authors Affiliations
  1. 1. Dept. of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Polish Journal of Medical Physics and Engineering Published:2021


Abstract

Spatially fractionated radiation therapy (SFRT) refers to the delivery of a single large dose of radiation within the target volume in a heterogeneous pattern using either a custom GRID block, multileaf collimators, and virtual methods such as helical tomotherapy or synchrotron-based microbeams. The potential impact of this technique on the regression of bulky deep-seated tumors that do not respond well to conventional radiotherapy has been remarkable. To date, a large number of patients have been treated using the SFRT techniques. However, there are yet many technical and medical challenges that have limited their routine use to a handful of clinics, most commonly for palliative intent. There is also a poor understanding of the biological mechanisms underlying the clinical efficacy of this approach. In this article, the methods of SFRT delivery together with its potential biological mechanisms are presented. Furthermore, technical challenges and clinical achievements along with the radiobiological models used to evaluate the efficacy and safety of SFRT are highlighted. © 2021 Farshid Mahmoudi et al., published by Sciendo 2021.
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