Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study Publisher



Asgharian A1 ; Mohammadi V2 ; Gholi Z2 ; Esmaillzade A3 ; Feizi A4 ; Askari G2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Shahrekord University of Medical Sciences, Shahrekord, IR, Iran
  2. 2. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IR, Iran
  3. 3. Department of Community Nutrition, School of Nutrition Sciences & Dietetics, Tehran University of Medical Sciences, Tehran, IR, Iran
  4. 4. Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, IR, Iran

Source: Iranian Red Crescent Medical Journal Published:2017


Abstract

Background: Regarding the growing prevalence of non-alcoholic fatty liver disease, concentrating on various strategies for its prevention and management seems necessary. Objectives: This study aimed to assess the effects of synbiotic administration on body composition and lipid profile in patients with NAFLD. Methods: Eighty patients with NAFLD participated in this randomized, double-blind, placebo-controlled clinical trial (from March to July 2014) in Iran. Based on AST and ALT as main variables of the study, 34 patients were required in each group (power 80% and α = 5%). Considering a 20% sample loss, 80 patients were enrolled. Synbiotic supplement in form of a 500 mg capsule (containing 7 species of probiotic bacteria and Fructooligosaccharides) was administrated to patients in the intervention group and those in the placebo group received 1 placebo capsule daily for 8 weeks. At the baseline and the end of the study, body composition and lipid profile were evaluated. Results: A significant reduction was observed in weight (P = 0.001), body fat (P = 0.02), and total cholesterol (P = 0.04) within the synbiotic group. Onthe other hand,WC(P = 0.02), total cholesterol, and LDL-c (P = 0.04 and P = 0.001, respectively) were significantly increased in the placebo group. TG, HDL-c, and FBG levels remained statistically unchanged in both groups. Significance betweengroup differences were seen in total cholesterol (P = 0.01), LDL (P = 0.01), weight, WC, and body fat after adjustment for energy intake (P = 0.05). Conclusions: Synbiotic supplementation may improve lipid profile and body composition in patients with NAFLD and might be useful in prevention of the disease progression. © 2017, Iranian Red Crescent Medical Journal.
Related Docs
View other Related Docs
1. The Effect of Symbiotic Supplementation on Liver Enzymes, C‑Reactive Protein and Ultrasound Findings in Patients With Non‑Alcoholic Fatty Liver Disease: A Clinical Trial, International Journal of Preventive Medicine (2016)
2. Probiotics As a Novel Treatment for Non-Alcoholic Fatty Liver Disease; a Systematic Review on the Current Evidences, Hepatitis Monthly (2013)
3. Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents, Journal of Pediatric Gastroenterology and Nutrition (2017)
4. Efficacy of Synbiotic Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials: Synbiotic Supplementation and Nafld, Critical Reviews in Food Science and Nutrition (2019)
5. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
6. Appetite Sensation Improvement by Synbiotic Supplementation in Patients With Metabolic Syndrome: A Randomized Controlled Clinical Trial, Food Science and Nutrition (2024)
7. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
8. Intake of Nutrients, Fiber, and Sugar in Patients With Nonalcoholic Fatty Liver Disease in Comparison to Healthy Individuals, International Journal of Preventive Medicine (2016)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (22)
Awat Feizi (19)
Other Related Docs
9. Adherence to Low Carbohydrate Diets and Non-Alcoholic Fatty Liver Disease: A Case Control Study, BMC Nutrition (2022)
10. The Association Between the Dietary Inflammatory Index (Dii) and Some Serum Oxidative Stress Markers in Non-Alcoholic Fatty Liver Disease: Case-Control, International Journal of Preventive Medicine (2022)
11. Effect of a Moderately Carbohydrate-Restricted Diet on Liver Enzymes, Steatosis and Fibrosis in Normal-Weight Individuals With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Parallel Randomised Controlled Clinical Trial, BMJ Open (2023)
12. The Association Between Major Dietary Patterns With the Risk of Non-Alcoholic Fatty Liver Disease, Oxidative Stress and Metabolic Parameters: A Case–Control Study, Journal of Diabetes and Metabolic Disorders (2022)
13. Effects of Synbiotic Consumption on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, European Journal of Nutrition (2020)
14. The Effect of Daily Consumption of Probiotic Yogurt on Liver Enzymes, Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Study Protocol for a Randomized Clinical Trial, BMC Gastroenterology (2022)
15. The Effect of a Mediterranean Diet on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
16. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
17. Effect of Sour Tea Supplementation on Liver Enzymes, Lipid Profile, Blood Pressure, and Antioxidant Status in Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Clinical Trial, Phytotherapy Research (2021)
18. The Effects of Synbiotic Supplementation on Some Cardio-Metabolic Risk Factors in Overweight and Obese Children: A Randomized Triple-Masked Controlled Trial, International Journal of Food Sciences and Nutrition (2013)
19. Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition (2021)
20. The Effects of Probiotic and Synbiotic Supplementation on Metabolic Syndrome Indices in Adults at Risk of Type 2 Diabetes: Study Protocol for a Randomized Controlled Trial, Trials (2017)
21. The Effect of Curcumin Pill in Treatment of Non-Alcoholic Fatty Liver Disease: A Clinical Trial Study, Journal of Isfahan Medical School (2017)
22. Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: A Critical and Systematic Review of Clinical Trials, Critical Reviews in Food Science and Nutrition (2019)
23. The Efficacy of Vitamin D Supplementation Against Nonalcoholic Fatty Liver Disease: A Meta-Analysis, Journal of Dietary Supplements (2020)
24. Association Between Lifelines Diet Score With Odds of Nonalcoholic Fatty Liver Disease and Some Novel Anthropometric Indices Among Adults: A Case–Control Study, Frontiers in Nutrition (2024)
25. Effects of Probiotics and Synbiotic on Lipid Profiles in Adults at Risk of Type 2 Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Functional Foods in Health and Disease (2019)
26. Effects of Pro-/Synbiotic Supplementation on Anthropometric and Metabolic Indices in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2019)
27. Dietary Advanced Glycation End Products Are Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2023)
28. The Relationship Between Dietary Antioxidant Intake and Physical Activity Rate With Nonalcoholic Fatty Liver Disease (Nafld): A Case – Control Study, Clinical Nutrition ESPEN (2019)
29. Effect of Pioglitazone on Nonalcoholic Fatty Liver Disease in Morbid Obese Patients; a Randomized Controlled Trial, Advanced Biomedical Research (2023)
30. The Effects of Low Carbohydrate Diets on Liver Function Tests in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Research in Medical Sciences (2016)
31. Vitamin E + Ursodeoxycholic Acid (Udca) Versus Vitamin E for the Treatment of Non-Alcoholic Steatohepatitis (Nash), Journal of Isfahan Medical School (2010)
32. Adaptation of Clinical Practice Guideline for Assessment of Liver Fibrosis in Patients With Non Alcoholic Fatty Liver Disease in Isfahan Province, International Journal of Preventive Medicine (2024)
33. Carbohydrate Quality Index and Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2024)
34. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Preventive Medicine (2015)
35. Dietary Patterns and Risk of Non-Alcoholic Fatty Liver Disease, BMC Gastroenterology (2021)
36. The Effect of Sesame Oil Consumption Compared to Sunflower Oil on Lipid Profile, Blood Pressure, and Anthropometric Indices in Women With Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind Controlled Trial, Trials (2022)
37. The Effect of Vitamin D Supplementation on Insulin Resistance in Patients With Nonalcoholic Fatty Liver, Journal of Isfahan Medical School (2015)
38. Effects of Synbiotics Supplementation on Anthropometric and Lipid Profile Parameters: Finding From an Umbrella Meta-Analysis, Frontiers in Nutrition (2023)
39. Treatment of Non-Alcoholic Fatty Liver Disease With Curcumin: A Randomized Placebo-Controlled Trial, Phytotherapy Research (2016)
40. Effects of Synbiotic Supplementation on Anthropometric Indices and Body Composition in Overweight or Obese Children and Adolescents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, World Journal of Pediatrics (2023)
41. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
42. Effects of the Mixture of Melissa Officinalis L., Cinnamomum Zeylanicutn and Urtica Dioica on Hepatic Enzymes Activity in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Pharmacology (2012)
43. The Effects of Probiotics on Body Weight and Biomarkers of Animal, Pakistan Journal of Nutrition (2013)
44. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
45. The Effect of Probiotics on Lipid Profile & Anthropometric Indices in Diabetic Nephropathy; a Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2021)
46. The Effects of Metformin Administration on Liver Enzymes and Body Composition in Non-Diabetic Patients With Non-Alcoholic Fatty Liver Disease And/Or Non-Alcoholic Steatohepatitis: An Up-To Date Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
47. Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group, Journal of Isfahan Medical School (2016)
48. The Effects of Curcumin Supplementation on Liver Function, Metabolic Profile and Body Composition in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
49. The Effects of Sumac (Rhus Coriaria L.) Powder Supplementation in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial, Complementary Therapies in Clinical Practice (2020)
50. Efficacy of Synbiotic Supplementation in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Critical Reviews in Food Science and Nutrition (2020)