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Anxiolytic Effects of Echium Amoenum on the Elevated Plus-Maze Model of Anxiety in Mice Publisher Pubmed



Rabbani M1 ; Sajjadi SE2 ; Vaseghi G1 ; Jafarian A1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Sch. Pharm. and Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Hezar Jerib Avenue, Iran
  2. 2. Department of Pharmacognosy, Sch. Pharm. and Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Hezar Jerib Avenue, Iran

Source: Fitoterapia Published:2004


Abstract

The ethanolic extract of Echium amoenum flowers at the dose of 50 mg/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze (EPM) and decreased the percentage of time-spent in the closed arms of EPM. Moreover, it prolonged the ketamine-induced latency to sleep but had no significant effects on total sleeping time induced by ketamine. Also, the locomotor activity was affected but not to the same extent as observed for diazepam. These results suggested that the extract of E. amoenum seems to possess anxiolytic effect with lower sedative activity than that of diazepam. © 2004 Elsevier B.V. All rights reserved.
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