Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Skin Side Effects of Topical Glucantime in Patients With Cutaneous Leishmaniasis



Nilforoushzadeh MA1 ; Nilforoushan Z2 ; Jafari F1 ; Heidari A2 ; Ansari N2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Cutaneous leishmaniasis (CL) is endemic in many parts of Iran and is discussed as a health issue. Although it has spontaneously remitting course, but the treatment is often recommended to shorten the duration of illness and limit the size of the scar. First-line therapy is topical or systemic glucantime; but because of its serious complications, it is attempted to find better drugs with fewer side effects. This study aimed to assess the skin reactions in patients with cutaneous leishmaniasis treated with topical glucantime. Methods: This prospective cohort study was performed on all patients with cutaneous leishmaniasis treated with topical glucantime and referred to the Skin and Leishmaniasis Research Center, Isfahan, in 2010-2011. Skin side effects caused by this type of the treatment were analyzed. Findings: 130 patients with cutaneous leishmaniasis treated with topical glucantime were studied. The mean age of the patients was 16.38 ± 23.97 years. In 38.5 percent of patients, skin side effects were observed that were mainly maculopapuler rashs with pruritic (12.3 percent). The mean duration of treatment initiation until the appearance of skin side effects was 12.66 ± 20.98 days. There was no significant relationship between the clinical type and the site of the lesions and the appearance of skin side effects (P > 0.05). Conclusion: Skin side effects were mainly maculopapuler rashes with pruritic in patients with cutaneous leishmaniasis treated with topical glucantime. According to skin side effects induced by topical glucantime, importance and necessity of the injection method and the use of adjuvant therapy is emphasized according to indications of topical treatment of patients with cutaneous leishmaniasis. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Effect of Intralesional Meglumine Antimoniate (Glucantime) Versus a Combination of Topical Trichloroacetic Acid 50% and Local Heat Therapy by Non-Ablative Radiofrequency on Cutaneous Leishmaniasis Lesions, Journal of Research in Medical Sciences (2012)
2. Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2014)
3. Cutaneous Leishmaniasis Reinfection: Skin Disease and Leishmaniasis Research Center, Isfahan, Iran, Journal of Isfahan Medical School (2015)
4. Comparison Between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-Controlled, Randomized Clinical Trial, Clinical and Experimental Dermatology (2006)
5. A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% With Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2017)
6. The Efficacy of Intralesional Meglumine Antimoniate (Glucantime) Versus a Combination of Topical Trichloroacetic Acid 50% and Local Heat Therapy by Non-Ablative Radiofrequency on Cutaneous Leishmaniasis Lesions, Journal of Isfahan Medical School (2012)
7. Comparison Between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-Controlled, Randomized Clinical Trial, Indian Journal of Dermatology (2006)
8. Comparison of Three Different Therapies for Cutaneous Leishmaniasis and Identification of the Etiologic Isolates in Isfahan, Iran, Archives of Iranian Medicine (2020)
Experts (# of related papers)
View all Related Experts
Seyed Hossein Hejazi (53)
Ali Asilian (17)
Other Related Docs
9. Effect of Combination Therapy With Systemic Glucantime and Pentoxifylline in the Treatment of Cutaneous Leishmaniasis, International Journal of Dermatology (2006)
10. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Carbon Dioxide Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Dermatology Research and Practice (2016)
11. Comparison Between the Efficacy of Photodynamic Therapy and Topical Paromomycin in the Treatment of Old World Cutaneous Leishmaniasis: A Placebo-Controlled, Randomized Clinical Trial, Journal of Isfahan Medical School (2012)
12. Comparative Effect of Topical Trichloroacetic Acid and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis, International Journal of Pharmacology (2006)
13. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Journal of Isfahan Medical School (2013)
14. The Efficacy of 5% Trichloroacetic Acid Cream in the Treatment of Cutaneous Leishmaniasis Lesions, Journal of Dermatological Treatment (2012)
15. A Randomized, Placebo-Controlled Trial of a Two-Week Regimen of Aminosidine (Paromomycin) Ointment for Treatment of Cutaneous Leishmaniasis in Iran, American Journal of Tropical Medicine and Hygiene (1995)
16. The Efficacy of Treatment With Intralesional Meglumine Antimoniate Alone, Compared With That of Cryotherapy Combined With the Meglumine Antimoniate or Intralesional Sodium Stibogluconate, in the Treatment of Cutaneous Leishmaniasis, Annals of Tropical Medicine and Parasitology (2003)
17. The Epidemiology of Cutaneous Leishmaniasis in Isfahan Province, Iran, During 2001-2011, Journal of Isfahan Medical School (2015)
18. Treatment of Recurrent Cutaneous Leishmaniasis, International Journal of Dermatology (1995)
19. Successful Treatment of Lupoid Cutaneous Leishmaniasis With Glucantime and Topical Trichloroacetic Acid (A Case Report), Korean Journal of Parasitology (2008)
20. The Efficacy of Achillea Millefolium Topical Gel Along With Intralesional Injection of Glucantime in the Treatment of Acute Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2012)
21. Antimonial Treatment Failure Rate in Patients With Cutaneous Leishmaniasis, Tehran University Medical Journal (2018)
22. Efficacy of Paromomycin Ointment in the Treatment of Cutaneous Leishmaniasis: Results of a Double-Blind, Randomized Trial in Isfahan, Iran, Annals of Tropical Medicine and Parasitology (2005)
23. Serum Monocyte Chemotactic Protein-1 and Nitric Oxide in Cutaneous Leishmaniasis Patients Before and After Treatment With Glucantime, Journal of Isfahan Medical School (2012)
24. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Itraconazole in the Treatment of Cutaneous Leishmaniasis, Journal of the European Academy of Dermatology and Venereology (2005)
25. Basal Cell Carcinoma Superimposed on a Cutaneous Leishmaniasis Lesion in an Immunocompromised Patient, Journal of Research in Medical Sciences (2012)
26. Reevaluating Leishmanin Skin Test As a Marker for Immunity Against Cutaneous Leishmaniasis, International Journal of Dermatology (2013)
27. Treatment of Glucantim™-Resistant Cutaneous Leishmaniasis Using Combination Therapy of Allopurinol and Trichloroacetic Acid (Tca) 50%; Report of Three Cases, Journal of Isfahan Medical School (2017)
28. Efficacy of Adjunctive Topical Liposomal Clarithromycin on Systemic Glucantime in Old World Cutaneous Leishmaniasis: A Pilot Clinical Study, Frontiers in Pharmacology (2023)
29. Treatment of Cutaneous Leishmaniasis With Ketoconazole Cream, Journal of Dermatological Treatment (2003)
30. Preparation and Evaluation of Clinical Effects of Glucantime Gel Mask, Journal of Isfahan Medical School (2013)
31. Clinical Picture of Cutaneous Leishmaniasis in Isfahan, Iran, International Journal of Dermatology (1994)
32. Isolation of Bacteria Causing Secondary Bacterial Infection in the Lesions of Cutaneous Leishmaniasis, Indian Journal of Dermatology (2008)
33. Evaluation of Leishmanin Skin Test and Its Relationship With the Clinical Form and Duration of Cutaneous Leishmaniasis, Dermatology Online Journal (2006)
34. Evaluation of Leishmanin Skin Test Reaction in Different Variants of Cutaneous Leishmaniasis, Indian Journal of Dermatology (2013)
35. Effect of Topical Honey Application Along With Intralesional Injection of Glucantime in the Treatment of Cutaneous Leishmaniasis, BMC Complementary and Alternative Medicine (2007)
36. Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study, Iranian Journal of Pharmaceutical Research (2021)
37. Electrocardiographic Changes in Patients With Cutaneous Leishmaniasis Treated With Systemic Glucantime, Annals of the Academy of Medicine Singapore (2008)
38. Comparison of Intralesionally Injected Zinc Sulfate With Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis, Dermatology (2004)
39. Epidemiological Aspects of Cutaneous Leishmaniasis in Iran, Archives of Clinical Infectious Diseases (2015)
40. Serum Monocyte Chemotactic Protein-1 and Nitric Oxide in Cutaneous Leishmaniasis Patients Before and After Treatment With Glucantime, Journal of Isfahan Medical School (2012)
41. Treatment of Cutaneous Leishmaniasis: Cassia Fistula Fruit Gel-Intralesional Glucantime Vs. Placebo Gel- Intralesional Glucantime Combination, Tehran University Medical Journal (2010)
42. Topical Effectiveness of Different Concentrations of Nanosilver Solution on Leishmania Major Lesions in Balb/C Mice, Journal of Vector Borne Diseases (2012)
43. Identification of Leishmania Species and Treatment Courses in Patients With Leishmaniasis in Isfahan, Iran, Journal of Isfahan Medical School (2012)
44. Comparative Study of the Efficacy of Combined Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime®) Vs. Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime®) Alone for the Treatment of Cutaneous Leishmaniasis, International Journal of Dermatology (2004)
45. Treatment of Cutaneous Leishmaniasis With Aminosidine (Paromomycin) Ointment: Double-Blind, Randomized Trial in the Islamic Republic of Iran, Bulletin of the World Health Organization (2003)
46. A Comparative Study Between the Efficacy of Systemic Meglumine Antimoniate Therapy With Standard or Low Dose Plus Oral Omeprazole in the Treatment of Cutaneous Leishmaniasis, Journal of Vector Borne Diseases (2008)
47. Pcr-Rflp Diagnosis and Characterization of Leishmania Species Causing Human Cutaneous Leishmaniasis and Evaluation of Treatment Times With Glucantime in These Patients, Tropical Biomedicine (2016)
48. The Comparison Between Trichloroacetic Acid 50% and Co2 Laser in the Treatment of Cutaneous Leishmaniasis Scar, Indian Journal of Dermatology (2011)
49. Distribution Frequency of Pathogenic Bacteria Isolated From Cutaneus Leishmaniasis Lesions, Korean Journal of Parasitology (2008)
50. Comparison of Healing Effects of Local Injection of Glucantime With or Without Trichloroacetic Acid 50% in Cutaneous Leshmaniasis, Journal of Isfahan Medical School (2009)