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Longitudinally Extensive Transverse Myelitis As a Sign of Multisystem Inflammatory Syndrome Following Covid-19 Infection: A Pediatric Case Report Publisher Pubmed



Pourmoghaddas Z1 ; Sadeghizadeh A2 ; Tara SZ3 ; Zandifar A4 ; Rahimi H1 ; Saleh R5 ; Ghazavi M6 ; Yaghini O6 ; Hosseini N6 ; Javadi N7 ; Saadatnia M8 ; Vossough A4
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Infectious, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatric Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States
  4. 4. Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States
  5. 5. Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pediatric Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Isfahan Neurosciences Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Neuroimmunology Published:2021


Abstract

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis. © 2021 Elsevier B.V.