Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1

Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1 Publisher Pubmed

Baghban N¹ ; Momeni S¹ ; Behboudi E² ; Dianatmoghadam H^{3, 4} ; Darabi A⁵ ; Targhi HS⁶ ; Keshavarz M⁵

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1. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2. Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran
3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5. The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
6. Influenza and Respiratory Viruses Department, Pasteur Institute of Iran, Tehran, Iran

Source: Virology Journal Published:2024

Abstract

Background: The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown promising results in the use of Arabic gum for the green synthesis of nanoparticles with strong antiviral properties. In this study we aimed to investigate the antiviral effects of MnO2 nanoparticles (MnO2-NPs) synthesized using Arabic gum, particularly against the influenza virus. Methods: Arabic gum was used as a natural polymer to extract and synthesize MnO2-NPs using a green chemistry approach. The synthesized MnO2-NPs were characterized using SEM and TEM. To evaluate virus titration, cytotoxicity, and antiviral activity, TCID50, MTT, and Hemagglutination assay (HA) were performed, respectively. Molecular docking studies were also performed to investigate the potential antiviral activity of the synthesized MnO2-NPs against the influenza virus. The molecular docking was carried out using AutoDock Vina software followed by an analysis with VMD software to investigate the interaction between Arabic gum and the hemagglutinin protein. Results: Simultaneous combination treatment with the green-synthesized MnO2-NPs resulted in a 3.5 log HA decrement and 69.7% cellular protection, which demonstrated the most significant difference in cellular protection compared to the virus control group (p-value < 0.01). The docking results showed that binding affinities were between − 3.3 and − 5.8 kcal/mole relating with the interaction between target with MnO2 and beta-D-galactopyranuronic acid, respectively. Conclusion: The results of the study indicated that the MnO2-NPs synthesized with Arabic gum had significant antiviral effects against the influenza virus, highlighting their potential as a natural and effective treatment for inhibition of respiratory infections. © The Author(s) 2024.

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Style	Citing Format
MLA	Baghban N, et al.. "Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1." Virology Journal, vol. 21, no. 1, 2024, pp. -.
APA	Baghban N, Momeni S, Behboudi E, Dianatmoghadam H, Darabi A, Targhi HS, Keshavarz M (2024). Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1. Virology Journal, 21(1), -.
Chicago	Baghban N, Momeni S, Behboudi E, Dianatmoghadam H, Darabi A, Targhi HS, Keshavarz M. "Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1." Virology Journal 21, no. 1 (2024): -.
Harvard	Baghban N et al. (2024) 'Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1', Virology Journal, 21(1), pp. -.
Vancouver	Baghban N, Momeni S, Behboudi E, Dianatmoghadam H, Darabi A, Targhi HS, et al.. Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1. Virology Journal. 2024;21(1):-.
BibTex	@article{ author = {Baghban N and Momeni S and Behboudi E and Dianatmoghadam H and Darabi A and Targhi HS and Keshavarz M}, title = {Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1}, journal = {Virology Journal}, volume = {21}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Baghban N AU - Momeni S AU - Behboudi E AU - Dianatmoghadam H AU - Darabi A AU - Targhi HS AU - Keshavarz M TI - Green Synthesis of Mno2 Nps Using Arabic Gum: Assessing Its Potential Antiviral Activity Against Influenza A/H1n1 JO - Virology Journal VL - 21 IS - 1 SP - EP - PY - 2024 ER -

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