Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Outcomes of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase Publisher Pubmed



Van De Munckhof A1 ; Lindgren E3, 4 ; Kleinig TJ5 ; Field TS6 ; Cordonnier C7 ; Krzywicka K1 ; Poli S8, 9 ; Sanchez Van Kammen M1 ; Borhanihaghighi A10 ; Lemmens R11 ; Scutelnic A12 ; Ciccone A14 ; Gattringer T15 ; Wittstock M16 Show All Authors
Authors
  1. Van De Munckhof A1
  2. Lindgren E3, 4
  3. Kleinig TJ5
  4. Field TS6
  5. Cordonnier C7
  6. Krzywicka K1
  7. Poli S8, 9
  8. Sanchez Van Kammen M1
  9. Borhanihaghighi A10
  10. Lemmens R11
  11. Scutelnic A12
  12. Ciccone A14
  13. Gattringer T15
  14. Wittstock M16
  15. Dizonno V6
  16. Devroye A11
  17. Elkady A17
  18. Gunther A18
  19. Cervera A19
  20. Mengel A8
  21. Chew BLA20
  22. Buck B21
  23. Zanferrari C22
  24. Garciaesperon C20
  25. Jacobi C23
  26. Soriano C24
  27. Michalski D25
  28. Zamani Z26
  29. Blacquiere D28
  30. Johansson E29
  31. Cuadradogodia E30
  32. Vuillier F31
  33. Bode FJ32
  34. Caparros F7
  35. Maier F33
  36. Tsivgoulis G34
  37. Katzberg HD35
  38. Duan J36
  39. Burrow J37
  40. Pelz J25
  41. Mbroh J8, 9
  42. Oen J38
  43. Schouten J39
  44. Zimmermann J32
  45. Ng K40
  46. Garambois K41
  47. Petruzzellis M42
  48. Carvalho Dias M43
  49. Ghiasian M44
  50. Romoli M45
  51. Miranda M46
  52. Wronski M40
  53. Skjelland M47
  54. Almasidooghaee M27
  55. Cuisenier P41
  56. Murphy S48
  57. Timsit S49
  58. Coutts SB50
  59. Schonenberger S51
  60. Nagel S51
  61. Hiltunen S52
  62. Chatterton S40
  63. Cox T53
  64. Bartsch T54
  65. Shaygannejad V55, 56
  66. Mirzaasgari Z27
  67. Middeldorp S57
  68. Levi MM2, 58
  69. Kremer Hovinga JA13
  70. Jood K3, 4
  71. Tatlisumak T4, 52
  72. Putaala J42
  73. Heldner MR12
  74. Arnold M12
  75. Aguiar De Sousa D59, 60
  76. Ferro JM60
  77. Coutinho JM1
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
  2. 2. Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Netherlands
  3. 3. Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
  4. 4. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
  5. 5. Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia
  6. 6. Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada
  7. 7. University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, France
  8. 8. Department of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Germany
  9. 9. Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Germany
  10. 10. Clinical Neurology Research Center, Shiraz University of Medical Sciences, Iran
  11. 11. Department of Neurology, University Hospitals Leuven, Belgium
  12. 12. Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
  13. 13. Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland
  14. 14. Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy
  15. 15. Department of Neurology, Medical University of Graz, Austria
  16. 16. Department of Neurology, University Hospital Rostock, Germany
  17. 17. Department of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia
  18. 18. Department of Neurology, Jena University Hospital, Germany
  19. 19. Royal Darwin Hospital, Darwin, NT, Australia
  20. 20. Department of Neurology, John Hunter Hospital, Newcastle, Australia
  21. 21. Division of Neurology, University of Alberta Hospital, Edmonton, Canada
  22. 22. Department of Neurology, Azienda Ospedaliera di Melegnano e Della Martesana, Italy
  23. 23. Department of Neurology, Krankenhaus Nordwest, Frankfurt am Main, Germany
  24. 24. Department of Neurology, Hospital General de Castellon, Castello, Spain
  25. 25. Department of Neurology, Leipzig University Hospital, Germany
  26. 26. Department of Neurology, Firoozabadi Hospital, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  27. 27. Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  28. 28. Division of Neurology, Ottawa Hospital, Canada
  29. 29. Department Clinical Science, Wallenberg Center for Molecular Medicine (WCMM), Umea University, Sweden
  30. 30. Department of Neurology, University Hospital del Mar, Barcelona, Spain
  31. 31. Stroke Unit, University Hospital of Besancon, France
  32. 32. Department of Neurology, Universitatsklinikum Bonn, Germany
  33. 33. Department of Neurology, Caritas Hospital Saarbrucken, Germany
  34. 34. Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Greece
  35. 35. Department of Neuromuscular Medicine, Toronto General Hospital, Canada
  36. 36. Department of Neurology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China
  37. 37. Department of Neurology, Royal Darwin Hospital, Tiwi, Australia
  38. 38. Department of Neurology, Antonius Ziekenhuis, Sneek, Netherlands
  39. 39. Department of Neurology, Rijnstate Hospital Arnhem, Netherlands
  40. 40. Department of Neurology, Royal North Shore Hospital, Sydney, Australia
  41. 41. Department of Neurology, CHU Grenoble Alpes, France
  42. 42. Department of Neurology, AOU Consorziale Policlinico di Bari, Italy
  43. 43. Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Portugal
  44. 44. Department of Neurology, Sina Hospital, Hamadan University of Medical Science, Iran
  45. 45. Neurology and Stroke Unit, Department of Neuroscience, Bufalini Hospital, Cesena, Italy
  46. 46. Department of Neurology, Hospital de Cascais Dr. Jose de Almeida, Cascais, Portugal
  47. 47. Department of Neurology, Oslo University Hospital, Norway
  48. 48. Acute Stroke Service, Mater Misericordiae University Hospital, UCD School of Medicine, RCSI Medical School, Dublin, Ireland
  49. 49. Department of Neurology, Stroke Unit, Hopital de la Cavale Blanche, CHRU de Brest (University Hospital), Universite de Bretagne Occidentale, Inserm 1078, Brest, France
  50. 50. Department of Clinical Neurosciences Radiology and Community Health Sciences, Foothills Medical Centre, Calgary, Canada
  51. 51. Department of Neurology, Heidelberg University Hospital, Germany
  52. 52. Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland
  53. 53. Department of Neurology, University Hospital Southampton NHS Foundation Trust, United Kingdom
  54. 54. Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany
  55. 55. Isfahan University of Medical Sciences (IUMS), Isfahan Neurosciences Research Center (INRC), Iran
  56. 56. Department of Internal (INRC), Iran
  57. 57. Department of Internal Medicine, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands
  58. 58. National Institute for Health Research, University College London Hospitals (UCLH), Biomedical Research Centre, London, United Kingdom
  59. 59. Stroke Centre, Lisbon Central University, Hospital Centre, Portugal
  60. 60. Instituto de Medicina Molecular Joao Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal

Source: Stroke Published:2022


Abstract

Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0-2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization). Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94-194). Two patients died during follow-up (3% [95% CI, 1%-11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%-94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed). Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up. © 2022 Lippincott Williams and Wilkins. All rights reserved.
Other Related Docs
12. Covid-19 Pneumonia and Pulmonary Embolism: Presentation of Four Cases, Indian Journal of Critical Care Medicine (2020)
21. Covid‑19’S Effect in Pregnancy and Vertical Transmission: A Systematic Review, International Journal of Preventive Medicine (2024)
27. Bleeding Diathesis or Prothrombotic State, Which One Predict the Covid-19 Prognosis in Pregnancy?, Journal of Obstetrics, Gynecology and Cancer Research (2021)
44. New-Onset Acute Ischemic Stroke Following Covid-19: A Case-Control Study, Journal of Research in Medical Sciences (2022)
49. Thrombocytopenia and Coronavirus: A Prognosis and Progression of the Coronavirus Disease, Iranian Journal of Pediatric Hematology and Oncology (2022)
50. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)