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Human Umbilical Cord-Derived Mesenchymal Stem Cells-Harvested Mitochondrial Transplantation Improved Motor Function in Tbi Models Through Rescuing Neuronal Cells From Apoptosis and Alleviating Astrogliosis and Microglia Activation Publisher Pubmed



Bamshad C1 ; Habibi Roudkenar M2 ; Abedinzade M3 ; Yousefzadeh Chabok S4 ; Pourmohammadibejarpasi Z2 ; Najafighalehlou N5 ; Sato T6 ; Tomita K6 ; Jahaniannajafabadi A7 ; Feizkhah A2 ; Mohammadi Roushandeh A2
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Burn and Regenerative Medicine Research Center, Velayat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Department of Operation Room, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran
  5. 5. Department of Medical Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
  7. 7. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Immunopharmacology Published:2023


Abstract

Each year, traumatic brain injury (TBI) causes a high rate of mortality throughout the world and those who survive have lasting disabilities. Given that the brain is a particularly dynamic organ with a high energy consumption rate, the inefficiency of current TBI treatment options highlights the necessity of repairing damaged brain tissue at the cellular and molecular levels, which according to research is aggravated due to ATP deficiency and reactive oxygen species surplus. Taking into account that mitochondria contribute to generating energy and controlling cellular stress, mitochondrial transplantation as a new treatment approach has lately reduced complications in a number of diseases by supplying healthy and functional mitochondria to the damaged tissue. For this reason, in this study, we used this technique to transplant human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)-derived mitochondria as a suitable source for mitochondrial isolation into rat models of TBI to examine its therapeutic benefit and the results showed that the successful mitochondrial internalisation in the neuronal cells significantly reduced the number of brain cells undergoing apoptosis, alleviated astrogliosis and microglia activation, retained normal brain morphology and cytoarchitecture, and improved sensorimotor functions in a rat model of TBI. These data indicate that human umbilical cord-derived mesenchymal stem cells-isolated mitochondrial transplantation improves motor function in a rat model of TBI via rescuing neuronal cells from apoptosis and alleviating astrogliosis and microglia activation, maybe as a result of restoring the lost mitochondrial content. © 2023 Elsevier B.V.
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