Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Investigation of Pregnancy Tendency, Reproductive Characteristics, and Disability in Women With Multiple Sclerosis: A Secondary Data Analysis of the National Registry in Iran Publisher



Ghane Ezabadi S1 ; Ashtari F2 ; Baghbanian SM3 ; Majdinasab N4 ; Madreseh E5 ; Hatamian H6 ; Faraji F7, 8 ; Bayati A9 ; Kamali H10 ; Sharifipour E11 ; Mozhdehipanah H12 ; Shahrbaf MA13 ; Ayoubi S1 ; Sahraian MA1 Show All Authors
Authors
  1. Ghane Ezabadi S1
  2. Ashtari F2
  3. Baghbanian SM3
  4. Majdinasab N4
  5. Madreseh E5
  6. Hatamian H6
  7. Faraji F7, 8
  8. Bayati A9
  9. Kamali H10
  10. Sharifipour E11
  11. Mozhdehipanah H12
  12. Shahrbaf MA13
  13. Ayoubi S1
  14. Sahraian MA1
  15. Eskandarieh S1
Show Affiliations
Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Musculoskeletal Rehabilitation Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Neurology, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran
  7. 7. Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  8. 8. Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
  9. 9. Department of Neurology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  10. 10. Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  11. 11. Department of Neurology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  12. 12. Department of Neurology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  13. 13. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Current Journal of Neurology Published:2024


Abstract

Background: Multiple sclerosis (MS) predominantly affects women of childbearing age, significantly impacting their quality of life (QOL). The diagnosis of MS can influence pregnancy intention, and the level of disability associated with MS may change before and after pregnancy. This study aims to analyze the reproductive characteristics of Iranian female patients with MS (PwMS) and their association with the Expanded Disability Status Scale (EDSS) and pregnancy tendency, providing valuable insights into disease progression and the development of tailored treatments. Methods: A cross-sectional study was conducted using data from the nationwide MS registry of Iran (NMSRI) from 2018 to 2021. Patients without a documented history of pregnancy, MS type, or EDSS score were excluded from the study. Various statistical methods, including nonparametric tests, the generalized estimating equation (GEE) model, and multiple logistic regression, were employed to analyze the data. Results: The study included 1120 PwMS with a median diagnostic age of 31 and a disease duration of 6 years. The majority had relapsing-remitting MS (RRMS) and the mean EDSS score at bassline was 1.5 ± 1.4. A history of pregnancy or abortion was associated with higher EDSS scores. Multiparity before MS diagnosis was linked to EDSS score ≥ 5, while this EDSS range was associated with decreased parity after MS diagnosis (all P-values < 0.05). Conclusion: Pregnancy and parity can affect the disability in female PwMS irrespective of clinical symptoms, diagnosis age, and MS type. Moreover, the chance of parity may be affected by a higher disability score, which should be considered in the clinical setting. © 2024 Iranian Neurological Association, and Tehran University of Medical Sciences
Related Docs
View other Related Docs
1. Consanguineous Marriage Among Familial Multiple Sclerosis Subjects: A National Registry-Based Study, Heliyon (2024)
2. Late-Onset Multiple Sclerosis in Iran: A Report on Demographic and Disease Characteristics, Multiple Sclerosis and Related Disorders (2023)
3. Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study, Clinical Neurology and Neurosurgery (2024)
4. Economic and Social Standing of Individuals in Iran Diagnosed With Multiple Sclerosis, Archives of Iranian Medicine (2023)
5. Investigating the Interaction Between Fertility, Pregnancy, and Multiple Sclerosis, Journal of Education and Health Promotion (2021)
6. Epidemiology of Familial Multiple Sclerosis in Iran: A National Registry-Based Study, BMC Neurology (2022)
7. Epidemiology of Multiple Sclerosis in Iran: A Systematic Review, European Neurology (2013)
8. Cesarean Delivery May Increase the Risk of Multiple Sclerosis, Multiple Sclerosis Journal (2012)
Experts (# of related papers)
View all Related Experts
Vahid Shaygannejad (79)
Masoud Etemadifar (51)
Other Related Docs
9. Reciprocal Effects of Multiple Sclerosis, Childbirth, and Postpartum, Iranian Journal of Neonatology (2018)
10. Better Prognosis of Multiple Sclerosis in Patients Who Experienced a Full-Term Pregnancy, European Neurology (2012)
11. Increasing Female Preponderance of Multiple Sclerosis in Isfahan, Iran: A Population-Based Study, Multiple Sclerosis (2010)
12. The Role of Parental Consanguinity and Familial Aggregation in Development of Multiple Sclerosis: A Case-Control Study, European journal of medical research (2024)
13. Risk Factors of Early Onset of Ms in Women in Reproductive Age Period: Survival Analysis Approach, Archives of Women's Mental Health (2016)
14. Assessing the Risk Factors for Multiple Sclerosis in Women of Reproductive Age Suffering the Disease in Isfahan Province, International Journal of Preventive Medicine (2016)
15. Male Sex Is Independently Associated With Faster Disability Accumulation in Relapse-Onset Ms But Not in Primary Progressive Ms, PLoS ONE (2015)
16. Risk Factors of Multiple Sclerosis and Their Relation With Disease Severity: A Cross-Sectional Study From Iran, Archives of Iranian Medicine (2016)
17. A National Registry-Based Study of Ethnic Differences in People With Multiple Sclerosis in Iran, Clinical Neurology and Neurosurgery (2024)
18. Pregnancy and Multiple Sclerosis, Neurological Disorders and Pregnancy (2011)
19. Prevalence and Incidence of Multiple Sclerosis in Isfahan, Iran Between 1996 and 2021: A Population-Based Study, Multiple Sclerosis and Related Disorders (2024)
20. Estimated Prevalence and Incidence of Multiple Sclerosis in Iran, European Neurology (2014)
21. Multiple Sclerosis National Registry System in Iran: Validity and Reliability of a Minimum Data Set, Multiple Sclerosis and Related Disorders (2019)
22. Pregnancy and Multiple Sclerosis, Neurological Disorders and Pregnancy (2010)
23. Sharp Increase in the Incidence and Prevalence of Multiple Sclerosis in Isfahan, Iran, Multiple Sclerosis Journal (2011)
24. Lateonset Multiple Sclerosis in Isfahan, Iran, Archives of Iranian Medicine (2012)
25. Variability of the Response to Immunotherapy Among Subgroups of Patients With Multiple Sclerosis, European Journal of Neurology (2023)
26. Cancer and Mortality Risks Among People With Multiple Sclerosis: A Population-Based Study in Isfahan, Iran, PLoS ONE (2024)
27. Sexual Dysfunction in Women With Multiple Sclerosis: Dimensions and Contributory Factors, Journal of Research in Medical Sciences (2014)
28. Clinical Characteristics and Disability Progression of Early-And Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis, Journal of Clinical Medicine (2020)
29. External Validation of a Clinical Prediction Model in Multiple Sclerosis, Multiple Sclerosis Journal (2023)
30. Multiple Sclerosis in Isfahan, Iran, International Review of Neurobiology (2007)
31. Disability Accrual in Primary and Secondary Progressive Multiple Sclerosis, Journal of Neurology, Neurosurgery and Psychiatry (2023)
32. Ongoing Increase in Incidence and Prevalence of Multiple Sclerosis in South-Eastern Iran: A Three Decade Study, Multiple Sclerosis and Related Disorders (2023)
33. Prevalence of Multiple Sclerosis in Isfahan, Iran, Neuroepidemiology (2006)
34. Clinical and Epidemiological Aspects of Multiple Sclerosis in Children, Iranian Journal of Child Neurology (2017)
35. Stress Differentially Predicts Multiple Sclerosis Relapses, Neurology Asia (2014)
36. Multiple Sclerosis Severity Score (Msss) Improves the Accuracy of Individualized Prediction in Ms, Multiple Sclerosis Journal (2022)
37. Comparison of Disability in Patients With Multiple Sclerosis With and Without Familial History, Journal of Isfahan Medical School (2022)
38. Disease Activity in Pregnant and Postpartum Women With Multiple Sclerosis Receiving Ocrelizumab or Other Disease-Modifying Therapies, Neurology: Neuroimmunology and NeuroInflammation (2024)
39. Effectiveness of Multiple Disease-Modifying Therapies in Relapsing-Remitting Multiple Sclerosis: Causal Inference to Emulate a Multiarm Randomised Trial, Journal of Neurology, Neurosurgery and Psychiatry (2023)
40. Prenatal and Perinatal Factors Associated With Developing Multiple Sclerosis Later in Life: A Systematic Review and Meta-Analysis, Autoimmunity Reviews (2021)
41. Sexual Dysfunction in Women With Multiple Sclerosis: Prevalence and Impact on Quality of Life, BMC Urology (2020)
42. Effect of Disease-Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years, Neurology (2021)
43. The Global Prevalence of Familial Multiple Sclerosis: An Updated Systematic Review and Meta-Analysis, BMC Neurology (2021)
44. The Frequency of Cognitive Dysfunction Among Multiple Sclerosis Patients With Mild Physical Disability, Journal of Isfahan Medical School (2012)
45. Prescription Trends of Disease-Modifying Treatments for Multiple Sclerosis in Iran Over the Past 30 Years, Multiple Sclerosis and Related Disorders (2022)
46. Sex As a Determinant of Relapse Incidence and Progressive Course of Multiple Sclerosis, Brain (2013)
47. Utilization of Multiple Sclerosis Therapies in the Middle East Over a Decade: 2009–2018, CNS Drugs (2021)
48. Working Memory Dysfunction Differs Between Secondary Progressive and Relapsing Multiple Sclerosis: Effects of Clinical Phenotype, Age, Disease Duration, and Disability, Multiple Sclerosis and Related Disorders (2023)
49. Stability of Mental Toughness, Sleep Disturbances, and Physical Activity in Patients With Multiple Sclerosis (Ms)-A Longitudinal and Pilot Study, Frontiers in Psychiatry (2018)
50. Safety of Sinopharm Vaccine for People With Multiple Sclerosis: Study of Adverse Reactions and Disease Activity, Multiple Sclerosis and Related Disorders (2022)