Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Expression of Cytoskeletal Proteins in Kidney Specimens of Children With Primary Focal Segmental Glomerulosclerosis Publisher



Gheissari A1 ; Taheri D2 ; Mozafarpour S3 ; Beigy H3 ; Samanianpoor P3 ; Merrikhi A4 ; Farajzadegan Z5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Iran
  4. 4. Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Iran
  5. 5. Department of Social Medicine, Iran

Source: Indian Journal of Nephrology Published:2012


Abstract

Several studies have evaluated cytoskeletal proteins as prognostic factors for some types of nephrotic syndrome. However, studies concerning children with FSGS are scarce. This study was done to evaluate the glomerular, tubular, and interstitial expression of vimentin, desmin, and alpha smooth muscle actin (α-SMA) in kidney specimens of children with FSGS. Clinical and histologic data of 31 children with FSGS were reviewed. Thirty one formalin-fixed, paraffin-embedded kidney biopsy sections (3 μm) were selected for immunohistochemical staining. Double immunohistochemistry using a microwave-based two-color staining was applied. The mean age at onset in male and female was 56.3 ± 41.4 and 78.0 ± 60.4 months, respectively. The duration of follow-up was 46.3 ± 56.5 months. Interstitial fibrosis and tubular atrophy were reported in 42% and 54% of the patients, respectively. The latest evaluated mean blood pressure was significantly correlated with the expression of both vimentin and α-SMA in the interstitium (P < 0.05). However, we were not able to demonstrate any cytoskeletal protein expression as an independent predictor for renal survival. Further studies with larger sample size and longer follow-up periods are warranted to investigate the prognostic values of other histopathologic features in pediatrics with FSGS.
Related Docs
View other Related Docs
1. A Study on Variants of Focal Segmental Glomerulosclerosis and Their Relationship With Various Biochemical and Demographic Parameters in Kidney Biopsies; a Single Center Study, Journal of Nephropharmacology (2019)
2. The Predictive Role of Histopathological Findings in Renal Insufficiency and Complete Remission in a Sample of Iranian Adults With Primary Focal Segmental Glomerulosclerosis, Journal of Research in Medical Sciences (2010)
3. Long-Term Outcome of Steroid-Resistant Nephrotic Syndrome in Children, Journal of the American Society of Nephrology (2017)
4. Association of Neutrophil Gelatinase Associated Lipocalin and Cystatin-C With Kidney Function in Children With Nephrotic Syndrome, International Journal of Preventive Medicine (2013)
5. Prediction of Kidney Survival in Children With Primary Focal Segmental Glomerulosclerosis (A Two-Center Study), Journal of Research in Medical Sciences (2007)
6. Morphologic Lesions of Membranous Nephropathy in Association With Various Demographic and Laboratory Parameters of Patients; a Single Center Study, Journal of Nephropharmacology (2020)
7. The Effect of Parental Consanguinity on Clinical Course and Outcome of Children With Focal Segmental Glomerulosclerosis, a Report From Isfahan, Iran, Iranian Journal of Kidney Diseases (2020)
8. Trpc6 Mutational Analysis in Iranian Children With Focal Segmental Glomerulosclerosis, Iranian Journal of Kidney Diseases (2018)
Experts (# of related papers)
View all Related Experts
Alaleh Gheissari (19)
Alireza Merrikhi (9)
Other Related Docs
9. Complications of Children With Nephrotic Syndrome Hospitalized at Imam Hossein Pediatric Hospital, Isfahan, Iran, Journal of Isfahan Medical School (2016)
10. Chronic Kidney Disease in Iran: First Report of the National Registry in Children and Adolescences, Urology Journal (2021)
11. Association of Cd147 Renal Expression With Morphologic Lesions of Oxford Classification in Iga Nephropathy Patients, Journal of Renal Injury Prevention (2018)
12. Relationship of Cd147 Kidney Expression With Various Pathologic Lesions, Biochemical and Demographic Data in Patients With Classes Iii and Iv of Lupus Nephritis, Journal of Nephropathology (2018)
13. Significance of Extracapillary Proliferation in Iga-Nephropathy Patients With Regard to Clinical and Histopathological Variables, Hippokratia (2013)
14. The Relative Frequency, Clinical and Laboratory Findings of Adult Glomerulonephritidies in Tehran, Journal of Research in Medical Sciences (2006)
15. Pruritus Features in Children With End-Stage Renal Disease Underwent Dialysis: A Cross-Sectional Study, International Journal of Pediatrics (United Kingdom) (2021)
16. R229q Polymorphism of Nphs2 Gene in Patients With Late-Onset Steroid-Resistance Nephrotic Syndrome a Preliminary Study, Iranian Journal of Kidney Diseases (2013)
17. A Six-Year Survey of the Spectrum of Renal Disorders on Native Kidney Biopsy Results in Central Iran and a Review of Literature, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2018)
18. Oxford-Mest Classification in Iga Nephropathy Patients: A Report From Iran, Journal of Nephropathology (2012)
19. Association of Glomerular C4d Deposition With Various Demographic Data in Iga Nephropathy Patients; a Preliminary Study, Journal of Nephropathology (2015)
20. The Quality of Life in Children With Nephritic Syndrome in Isfahan, Iran, Journal of Isfahan Medical School (2013)
21. Chronic Kidney Disease in Children: A Report From a Tertiary Care Center Over 11 Years, Journal of Nephropathology (2012)
22. Gene Mutation Analysis in Iranian Children With Nephronophthisis: A Two-Center Study, Iranian Journal of Kidney Diseases (2015)
23. Genetic Screening in Adolescents With Steroid-Resistant Nephrotic Syndrome, Kidney International (2013)
24. Prevalence and Clinical Findings of Biopsy-Proven Glomerulonephritidis in Iran., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2007)
25. Ki-67 Proliferative Index in Immunoglobulin a Nephropathy; a Pilot Study, Immunopathologia Persa (2022)
26. Comparing the Urinary Value of N-Acetyl-Β-D-Glucosaminidase (Nag) and Β2-Microglobulinuria (Β2m) in Acute Kidney Damage in Children, Journal of Isfahan Medical School (2013)
27. Is Ckd Screening Program Necessary in Developing Countries?, Iranian Journal of Kidney Diseases (2023)
28. Anti-Phospholipase A2 Receptor Antibody in Idiopathic Membranous Nephropathy: A Report From Iranian Population, Journal of Nephropathology (2013)
29. Comparing Nphs2 and Wt1 Mutations in Children With Nephrotic Syndrome, Journal of Isfahan Medical School (2013)
30. A Workshop on Urinalysis and a Survey on Urine Microscopy Among Kidney Centers of Iran, Iranian Journal of Kidney Diseases (2013)
31. Kidney Function in Obese Adolescents With or Without Metabolic Syndrome in a Nationally-Representative Sample of Pediatric Population: First Report From the Middle East and North Africa: The Caspian-Iii Study: A Case-Control Study, Journal of Research in Medical Sciences (2013)
32. Chronic Kidney Disease Stages 3-5 in Iranian Children: Need for a School-Based Screening Strategy: The Caspian-Iii Study, International Journal of Preventive Medicine (2013)
33. Association of Proteinuria With Various Clinical Findings and Morphologic Variables of Oxford Classification in Immunoglobulin a Nephropathy Patients, International Journal of Preventive Medicine (2013)
34. Chronic Kidney Disease in Isfahan Province, Action Plan for Screening in a Population-Based Study, Iranian Journal of Kidney Diseases (2022)
35. Do Kidney Sizes in Ultrasonography Correlate to Glomerular Filtration Rate in Healthy Children?, Australasian Radiology (2007)
36. Renal Function Markers in Single-Kidney Patients After Percutaneous Nephrolithotomy: A Pilot Study, Journal of Research in Medical Sciences (2022)
37. Fractional Excretion of Magnesium (Femg), a Marker for Tubular Dysfunction in Children With Clinically Recovered Ischemic Acute Tubular Necrosis., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2011)
38. Clinicopathological Correlations in Lupus Nephritis; a Single Center Experience, Journal of Nephropathology (2014)
39. Evaluating the Adequacy of Adults Renal Biopsy Specimens Conducted by Different Methods, Journal of Isfahan Medical School (2011)
40. Does the Simple Renal Cyst Treatment Improve Renal Function: A Pilot Study, Advanced Biomedical Research (2022)
41. First Report on the Percentiles of the Glomerular Filtration Rate in Iranian Children Using the 2009 Schwartz Equations, Iranian Journal of Medical Sciences (2018)
42. Angiotensin-Converting Enzyme Gene Polymorphism and the Progression Rate of Focal Segmental Glomerulosclerosis in Iranian Children, Nephrology (2008)
43. Heterozygosity Analysis of Polycystic Kidney Disease 1 Gene Microsatellite Markers for Linkage Analysis of Autosomal Dominant Polycystic Kidney Disease Type 1 in the Iranian Population, Journal of Research in Medical Sciences (2017)