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Prevalence of Dysphagia in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis Publisher Pubmed



Mirmosayyeb O1, 2 ; Ebrahimi N2 ; Shekarian A2 ; Afsharisafavi A3 ; Shaygannejad V1, 2 ; Barzegar M1, 2 ; Bagherieh S2
Authors
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Authors Affiliations
  1. 1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

Source: Journal of Clinical Neuroscience Published:2023


Abstract

Background: Dysphagia is a major disorder observed in patients with multiple sclerosis (MS), yet different prevalence rates are reported for it. Therefore, we designed this study to estimate the pooled prevalence of dysphagia in patients with MS. Method: We searched PubMed, Scopus, EMBASE, Web of Science, and gray literature including references from the identified studies, reviews studies, and conference abstracts which were published up to May 2022. Articles that were relevant to our topic and could provide information regarding the prevalence of dysphagia among MS patients were included; however, articles with self-report screening strategies were excluded. Results: The literature search found 997 articles. After eliminating duplicates, 672 articles remained. Two conference abstracts were included for final analysis. A total of 11,266 MS cases and 5047 MS patients with dysphagia were included in the meta-analysis. The overall prevalence of dysphagia across all 54 studies was 44.8 % (95 % CI: [40.4 %–49.2 %]), with a high level of heterogeneity between countries (Q=; I2 = 94.96 %; p < 0.001). Conclusion: The results of this systematic review shows that the prevalence of dysphagia in MS patients is 45% which is greatly higher compared to the general population. © 2023 Elsevier Ltd
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