Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial Publisher Pubmed

Summary: Research suggests omega-3 supplements reduce inflammation in gas station workers exposed to pollutants, supporting immune balance. #Omega3 #Inflammation

Barkhordari S^{1, 2} ; Mirmosayyeb O^{3, 4} ; Mansourian M⁵ ; Hosseininasab F⁶ ; Ramezani S¹ ; Barzegar M¹ ; Amin MM² ; Poursafa P² ; Esmaeil N^{2, 6} ; Kelishadi R⁷
Source: Journal of Interferon and Cytokine Research Published:2020

Abstract

Environmental exposure to diesel particulate matter and commercial gasoline in gas station workers might induce oxidative stress and changes in the balance of the immune system. In this study, the immunomodulatory impacts of omega 3 fatty acid (ω3FA) supplement were assessed on inflammatory and anti-inflammatory markers in gas station workers in a double-blind placebo-controlled clinical trial. Fifty-three men working in gas stations were treated with ω3FA (n = 29) or placebo (n = 24) for 60 days. C-reactive protein, interleukin-12 (IL-12), transforming growth factor β (TGF-β), interferon γ(IFN-γ), tumor necrosis factor α, IL-10, and IL-17 levels were measured by enzyme-linked immunosorbent assay method before and after the completion of the trial. The concentrations of IFN-γand IL-17 were significantly decreased in ω3FA group compared with the placebo group (P < 0.001). Moreover, the levels of inhibitory cytokines including TGF-β and IL-10 significantly were increased in ω3FA group (P < 0.001). Overall, ω3FA nutritional supplementation can be useful in reducing inflammatory immune responses and maintaining immune tolerance in people with high exposure to inflammation-inducing factors. Color images are available online. © Copyright 2020, Mary Ann Liebert, Inc.