Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis

Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis Publisher Pubmed

Behjati M^{1, 4} ; Salehi M¹ ; Moghim S² ; Dashti GR³

Show Affiliations

1. Dept. of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
2. Dept. of Microbiology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
3. Dept. of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
4. Isfahan University of Medical Sciences, Faculty of Medicine, Dept. of Genetics, Isfahan 81744-176, Iran

Source: Acta Cardiologica Published:2007

Abstract

Objectives - There are some lines of evidence about the role of telomeres in atherosclerotic plaque formation and development. Despite the role of telomerase in telomere elongation and protection, its role in atherosclerosis is not fully understood. The present study was designed to evaluate the importance of alternative splicing variants of TERT (telomerase reverse transcriptase) in the atherosclerosis process. Methods and results - Six Dutch-Polish rabbits were fed a high-cholesterol diet, and six control animals a normal diet. Alternative splicing was assessed by RT-PCR in aortic endothelial cells of these rabbits. Fatty streaks formation was assessed by H & E staining of aortic tissues. There were no significant differences in variants of TERT in control and test animals; neither in endothelial cells nor in aortic vessel wall. Conclusion - Our results demonstrated that a decrease in telomerase activity in atherosclerosis formation is not due to TERT gene alternative splicing.

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Style	Citing Format
MLA	Behjati M, et al.. "Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis." Acta Cardiologica, vol. 62, no. 1, 2007, pp. 7-12.
APA	Behjati M, Salehi M, Moghim S, Dashti GR (2007). Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis. Acta Cardiologica, 62(1), 7-12.
Chicago	Behjati M, Salehi M, Moghim S, Dashti GR. "Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis." Acta Cardiologica 62, no. 1 (2007): 7-12.
Harvard	Behjati M et al. (2007) 'Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis', Acta Cardiologica, 62(1), pp. 7-12.
Vancouver	Behjati M, Salehi M, Moghim S, Dashti GR. Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis. Acta Cardiologica. 2007;62(1):7-12.
BibTex	@article{ author = {Behjati M and Salehi M and Moghim S and Dashti GR}, title = {Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis}, journal = {Acta Cardiologica}, volume = {62}, number = {1}, pages = {7-12}, year = {2007} }
RIS	TY - JOUR AU - Behjati M AU - Salehi M AU - Moghim S AU - Dashti GR TI - Evaluation of Tert Mrna Alternative Spliced Variants in Aortic Endothelial Cells of the Rabbit, in the Fatty Streaks Stage of Atherosclerosis JO - Acta Cardiologica VL - 62 IS - 1 SP - 7 EP - 12 PY - 2007 ER -

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