Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Polymorphic Aaag Repeat Length in Estrogen-Related Receptor Gamma (Errγ) and Risk of Breast Cancer in Iranian Women Publisher Pubmed



Karimi P1 ; Hematti S2 ; Safari F2 ; Tavassoli M1
Authors

Source: Cancer Investigation Published:2013


Abstract

Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ERRγ gene, a case-control study of 200 breast cancer patients and 200 controls was performed in Iranian women. Our results demonstrate that women with short AAAG repeat are at higher risk of breast cancer (OR 7). This result suggests a possible involvement of polymorphic AAAG repeat of ERRγ gene in regulating its expression. © 2013 Informa Healthcare USA, Inc.
Related Docs
View other Related Docs
1. Trinucleotide Repeat Polymorphism in Transforming Growth Factor Beta Receptor Type 1 Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
2. Tgfbr1 Polymorphism and Risk of Breast Cancer in Iranian Women, International Journal of Biological Markers (2015)
3. Ggcn Polymorphism of Erf3a/Gspt1 Gene and Breast Cancer Susceptibility, Medical Oncology (2012)
Experts (# of related papers)
View all Related Experts
Simin Hemati (11)
Maryam Derakhshan (1)
Other Related Docs
4. Association of the Length of Ca Dinucleotide Repeat in the Epidermal Growth Factor Receptor With Risk and Age of Breast Cancer Onset in Isfahan, Journal of Isfahan Medical School (2008)
5. The Prevalence of Ataxia Telangiectasia Mutated (Atm) Variants in Patients With Breast Cancer Patients: A Systematic Review and Meta-Analysis, Cancer Cell International (2021)
6. The Study of Taaaa Polymorphism in P53 Gene and Its Association With Breast Cancer, Journal of Isfahan Medical School (2015)
7. Polymorphisms of Satellite Dna Cyp19 Gene and Its Association With Increased Risk of Breast Cancer in Isfahan, Iran, Journal of Isfahan Medical School (2012)
8. Clinically Observed Estrogen Receptor Alpha Mutations Within the Ligand-Binding Domain Confer Distinguishable Phenotypes, Oncology (Switzerland) (2018)
9. Investigating of Variations in Brca1 Gene in Iranian Families With Breast Cancer, Medical Journal of the Islamic Republic of Iran (2018)
10. Oral Serd, a Novel Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer, Cancers (2024)
11. Multicentricity in Different Molecular Subtypes of Breast Cancer: A Cross-Sectional Study in Isfahan, Advanced Biomedical Research (2023)
12. The Relationship of Cac Polymorphism in Hoxa1 Gene and Breast Cancer, Journal of Isfahan Medical School (2014)
13. Association Between the Lengths of Gt Dinucleotide Repeat in the Pik3ca Gene With Breast Cancer Risk, Medical Oncology (2014)
14. Genomic Rearrangement Screening of the Brca1 From Seventy Iranian High-Risk Breast Cancer Families, Journal of Research in Medical Sciences (2016)
15. Frequent Esr1 and Cdk Pathway Copy-Number Alterations in Metastatic Breast Cancer, Molecular Cancer Research (2019)
16. Recurrent Hyperactive Esr1 Fusion Proteins in Endocrine Therapy-Resistant Breast Cancer, Annals of Oncology (2018)
17. Association of P53 (+16Ins-Arg) Haplotype With the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women, Journal of Kerman University of Medical Sciences (2018)
18. Fto Genotype Was Associated With Breast Cancer in Her2 Negative Patients, Clinical Nutrition ESPEN (2022)
19. Eukaryotic Release Factor 3 and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
20. The Association Between Ca Polymorphism in Src Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2017)