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Blood Lead Levels in Children With Neurological Disorders: A Single Centre Preliminary Study Pubmed



Mahmoudian T1 ; Modaresi M1 ; Zarei A2 ; Poursafa P3 ; Kelishadi R4
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Environmental Protection, Isfahan University of Technology, Isfahan, Iran
  4. 4. Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Chinese Journal of Contemporary Pediatrics Published:2009


Abstract

Objective: Lead poisoning is a potentially devastating problem among young children. Chronic low level lead exposure can lead to learning disabilities and behavior changes such as colic, insomnia, hyperactivity, impaired growth, hearing loss and upper extremity weakness. The purpose of this cross-sectional study was to determine the blood lead level in children with neurological disorders in comparison with healthy controls. Methods: Blood lead concentrations were measured by flame atomic absorption spectrometry in 100 children aged 1-10 years and suffering from various neurological disorders. One hundred age- and sex-matched healthy children served as controls. Results: The mean blood lead concentration was higher in children with neurological disorders than in controls (113.2 ± 47.5 μg/L vs 84.7 ± 38.0 μg/L; P <0.01). Overall, 44% of children with neurological disorders and 19% of controls were found to have increased blood lead levels, i. e. > 100 μg/L. Conclusions: An increase in blood lead level in children might be related to neurological disorders. The measurement of blood lead level might be included in diagnostic eveluation of children with neurological disorders.
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