Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Edta and Α-Tocopherol Improve the Chemical Stability of Astaxanthin Loaded Into Nanostructured Lipid Carriers Publisher



Tamjidi F1 ; Shahedi M1 ; Varshosaz J2 ; Nasirpour A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Food Science and Technology-Center of Excellence for Safety and Quality of Foods, College of Agriculture, Isfahan University of Technology, Isfahan, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Lipid Science and Technology Published:2014


Abstract

Nanostructured lipid carriers (NLC) as a promising delivery system have specific advantages over other nanocarriers for food applications. This study was aimed to evaluate the effect of different antioxidants on physical and chemical stability of NLC containing astaxanthin, a hydrophobic nutraceutical. Antioxidants (EDTA, ascorbic acid, α-tocopherol, coenzyme Q10) were added to aqueous and/or lipid phases. Tween 80 and lecithin were utilized as stabilizers; NLC formulations were produced by melt emulsification-sonication technique, and then stored at 35°C for 15 days. Except formulations with high levels of EDTA or ascorbic acid, others yielded small nanoparticles (Z-average ≈ 94nm) which were stable to growth during storage. Of these antioxidants, only EDTA and α-tocopherol increased the stability of astaxanthin without causing physical instability, and EDTA was more efficient. The utilization of α-tocopherol and EDTA in combination was more effective than using them individually. Storage temperature and artificial light had significant effects on the stability of astaxanthin in NLC. These results provide useful information for choosing antioxidants and storage conditions to further protection of nutraceuticals within NLC. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Related Docs
View other Related Docs
1. Design and Characterization of Astaxanthin-Loaded Nanostructured Lipid Carriers, Innovative Food Science and Emerging Technologies (2014)
2. Stability of Astaxanthin-Loaded Nanostructured Lipid Carriers As Affected by Ph, Ionic Strength, Heat Treatment, Simulated Gastric Juice and Freeze–Thawing, Journal of Food Science and Technology (2017)
3. Stability of Astaxanthin-Loaded Nanostructured Lipid Carriers in Beverage Systems, Journal of the Science of Food and Agriculture (2018)
4. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
5. Novel Hesperetin Loaded Nanocarriers for Food Fortification: Production and Characterization, Journal of Functional Foods (2013)
6. Β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, in Vitro Simulated Digestion and Hypocholesterolemic Activity, Pharmaceutics (2020)
7. Recent Progresses in the Delivery of Β-Carotene: From Nano/Microencapsulation to Bioaccessibility, Advances in Colloid and Interface Science (2022)
8. Formulation Optimization and Impact of Environmental and Storage Conditions on Physicochemical Stability of Pistachio Milk, Journal of Food Measurement and Characterization (2021)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (46)
Somayeh Taymouri (9)
Other Related Docs
9. Propolis Wax Nanostructured Lipid Carrier for Delivery of Β Sitosterol: Effect of Formulation Variables on Physicochemical Properties, Food Chemistry (2018)
10. Lycopene Nanodelivery Systems; Recent Advances, Trends in Food Science and Technology (2022)
11. Hesperetin-Loaded Solid Lipid Nanoparticles and Nanostructure Lipid Carriers for Food Fortification: Preparation, Characterization, and Modeling, Food and Bioprocess Technology (2013)
12. Formulation and Characterization of Novel Nanostructured Lipid Carriers Made From Beeswax, Propolis Wax and Pomegranate Seed Oil, Food Chemistry (2018)
13. Formulation of Ldl Targeted Nanostructured Lipid Carriers Loaded With Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and in Vitro Cytotoxicity, Journal of Nanomaterials (2012)
14. Freeze-Drying of Nanostructure Lipid Carriers by Different Carbohydrate Polymers Used As Cryoprotectants, Carbohydrate Polymers (2012)
15. Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules, Recent Patents on Nanotechnology (2021)
16. Edible Wax-Based Nanoparticles As Novel Stabilizers for Oil-In-Water Pickering Emulsion, Food and Bioprocess Technology (2023)
17. Release of Bioactive Compounds From Delivery Systems by Stimuli-Responsive Approaches; Triggering Factors, Mechanisms, and Applications, Advances in Colloid and Interface Science (2022)
18. Efavirenz Oral Delivery Via Lipid Nanocapsules: Formulation, Optimisation, and Ex-Vivo Gut Permeation Study, IET Nanobiotechnology (2018)
19. Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization, Journal of Dispersion Science and Technology (2012)
20. Protein-Polysaccharide Interactions for the Fabrication of Bioactive-Loaded Nanocarriers: Chemical Conjugates and Physical Complexes, Pharmacological Research (2022)
21. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
22. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
23. Biological Safety Evaluation of Stealth Solid Lipid Nanoparticles of Risperidone: Effect of Surface Characteristics on Their Hydrophobicity, Haemolysis and Macrophage Phagocytosis, Farmacia (2012)
24. Preparing Simvastatin Nanoparticles by a Combination of Ph-Sensitive and Timed-Release Approaches for the Potential Treatment of Ulcerative Colitis, Journal of Biomaterials Applications (2022)
25. Bixin-Loaded Colloidal Nanodelivery Systems, Techniques and Applications, Food Chemistry (2023)
26. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling, Journal of Nanomaterials (2013)
27. How Do Various Encapsulation Techniques Improve the Oral Delivery of Food Protein Hydrolysates?, Food Frontiers (2025)
28. Pharmaceutical Evaluation of Atorvastatin-Loaded Nanostructured Lipid Carriers Incorporated Into the Gelatin/Hyaluronic Acid/Polycaprolactone Scaffold for the Skin Tissue Engineering, Journal of Biomaterials Applications (2021)
29. Effects of Thermal Processing and Ph on the Physicochemical Properties, Stability, and Structure of Taxifolin-Loaded Nanostructured Lipid Carriers, Applied Food Research (2024)
30. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
31. Caffeine-Loaded Nano/Micro-Carriers: Techniques, Bioavailability, and Applications, Critical Reviews in Food Science and Nutrition (2024)
32. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
33. Factors Affecting the Production of Nanostructure Lipid Carriers of Valproic Acid, Journal of Biomedical Nanotechnology (2013)
34. Microencapsulation of Matricine by a Dehydrating Liquid and Assessment of Its Retention, Daru (2002)
35. Seed Gum-Based Delivery Systems and Their Application in Encapsulation of Bioactive Molecules, Critical Reviews in Food Science and Nutrition (2023)
36. Stability and Antimicrobial Effect of Amikacin-Loaded Solid Lipid Nanoparticles, International Journal of Nanomedicine (2011)
37. Colloidal Carriers of Almond Gum/Gelatin Coacervates for Rosemary Essential Oil: Characterization and In-Vitro Cytotoxicity, Food Chemistry (2022)
38. Carboxymethyl Cellulose-Based Wafer Enriched With Resveratrol-Loaded Nanoparticles for Enhanced Wound Healing, Drug Delivery and Translational Research (2020)
39. Co-Delivery of Paclitaxel and Α-Tocopherol Succinate by Novel Chitosan-Based Polymeric Micelles for Improving Micellar Stability and Efficacious Combination Therapy, Drug Development and Industrial Pharmacy (2015)
40. Formulation and Optimization of Solid Lipid Nanoparticles of Buspirone Hcl for Enhancement of Its Oral Bioavailability, Journal of Liposome Research (2010)
41. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
42. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
43. Formulation and Characterization of Doxorubicin Nanovesicles, Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics (2009)
44. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
45. Nanoencapsulation of Hydrophobic and Low-Soluble Food Bioactive Compounds Within Different Nanocarriers, Food Hydrocolloids (2019)
46. Colon-Specific Delivery of Mesalazine Chitosan Microspheres, Journal of Microencapsulation (2006)
47. Enhancement of Oral Bioavailability of Pentoxifylline by Solid Lipid Nanoparticles, Journal of Liposome Research (2010)
48. Cinnamaldehyde Encapsulation Within New Natural Wax-Based Nanoparticles; Formation, Optimization and Characterization, Journal of Dispersion Science and Technology (2023)
49. Galactosylated Nanostructured Lipid Carriers for Delivery of 5-Fu to Hepatocellular Carcinoma, Journal of Liposome Research (2012)
50. Optimization of Freeze-Drying Condition of Amikacin Solid Lipid Nanoparticles Using D-Optimal Experimental Design, Pharmaceutical Development and Technology (2012)