Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major

Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major Publisher Pubmed

Esmaeil N¹ ; Moayedi B¹ ; Gharagozloo M¹ ; Maracy MR²

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1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176, Hear Jerib Street, Iran
2. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Hemoglobin Published:2013

Abstract

Deposition of iron in visceral organs, mainly in the liver, causes tissue damage in β-thalassemia major (β-TM) patients. Keratin 18 (K18) represents one of the major caspase substrates during apoptosis of hepatocytes. To better characterize the hepatic apoptosis and/or necrosis in β-thal patients, the circulating levels of M65 (soluble intact K18) and M30 (the caspases-generated K18 fragment) were measured in 40 β-TM patients and compared with 40 healthy controls. The ratio of M30/M65 (caspase-cleaved to total K18) was also determined in thalassemic and normal subjects. Results of the ELISA assays revealed that the serum levels of hepatocyte death markers, M65 and M30, were significantly increased in β-thal patients compared to healthy controls (p <0.0001). M30 serum levels were also positively correlated with the serum levels of liver transaminases including aspartate aminotransferase (AST) (r = 0.337, p = 0.047) and alanine aminotransferase (ALT) (r =0.391, p = 0.02). © 2013 Informa Healthcare USA, Inc.

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Nafiseh Esmaeil (3)

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Style	Citing Format
MLA	Esmaeil N, et al.. "Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major." Hemoglobin, vol. 37, no. 4, 2013, pp. 404-410.
APA	Esmaeil N, Moayedi B, Gharagozloo M, Maracy MR (2013). Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major. Hemoglobin, 37(4), 404-410.
Chicago	Esmaeil N, Moayedi B, Gharagozloo M, Maracy MR. "Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major." Hemoglobin 37, no. 4 (2013): 404-410.
Harvard	Esmaeil N et al. (2013) 'Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major', Hemoglobin, 37(4), pp. 404-410.
Vancouver	Esmaeil N, Moayedi B, Gharagozloo M, Maracy MR. Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major. Hemoglobin. 2013;37(4):404-410.
BibTex	@article{ author = {Esmaeil N and Moayedi B and Gharagozloo M and Maracy MR}, title = {Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major}, journal = {Hemoglobin}, volume = {37}, number = {4}, pages = {404-410}, year = {2013} }
RIS	TY - JOUR AU - Esmaeil N AU - Moayedi B AU - Gharagozloo M AU - Maracy MR TI - Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, in Patients With Β-Thalassemia Major JO - Hemoglobin VL - 37 IS - 4 SP - 404 EP - 410 PY - 2013 ER -

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