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Non-Coding Rnas and Brain Tumors: Insights Into Their Roles in Apoptosis Publisher



Tamtaji OR1 ; Derakhshan M2 ; Rashidi Noshabad FZ3 ; Razaviyan J4 ; Hadavi R1 ; Jafarpour H5 ; Jafari A6, 7 ; Rajabi A3, 8 ; Hamblin MR9 ; Mahabady MK10 ; Taghizadieh M11 ; Mirzaei H12
Authors
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Authors Affiliations
  1. 1. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  7. 7. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Johannesburg, South Africa
  10. 10. Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  11. 11. Department of Pathology, School of Medicine, Center for Women’s Health Research Zahra, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Frontiers in Cell and Developmental Biology Published:2022


Abstract

A major terrifying ailment afflicting the humans throughout the world is brain tumor, which causes a lot of mortality among pediatric and adult solid tumors. Several major barriers to the treatment and diagnosis of the brain tumors are the specific micro-environmental and cell-intrinsic features of neural tissues. Absence of the nutrients and hypoxia trigger the cells’ mortality in the core of the tumors of humans’ brains: however, type of the cells’ mortality, including apoptosis or necrosis, has been not found obviously. Current studies have emphasized the non-coding RNAs (ncRNAs) since their crucial impacts on carcinogenesis have been discovered. Several investigations suggest the essential contribution of such molecules in the development of brain tumors and the respective roles in apoptosis. Herein, we summarize the apoptosis-related non-coding RNAs in brain tumors. Copyright © 2022 Tamtaji, Derakhshan, Rashidi Noshabad, Razaviyan, Hadavi, Jafarpour, Jafari, Rajabi, Hamblin, Mahabady, Taghizadieh and Mirzaei.
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