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Is It Necessary to Perform Connective Tissue Disorders Laboratory Tests When a Patient Experiences the First Demyelinating Attack?



Etemadifar M2, 3, 4 ; Fatemi A5 ; Hashemijazi H1, 2 ; Kazemizadeh A2
Authors
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Authors Affiliations
  1. 1. Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Eye Research Center, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Departments of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2013

Abstract

Background: It may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases. Materials and Methods: A total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antiβ2-Glycoprotein I antibody (IgG, IgM), anticardiolipin antibody (IgM, IgG), lupus anticoagulant, anti-double strand DNA (anri-ds DNA), antinuclear antibody (ANA), anti-myeloperoxidae (p-ANCA), and anti-Proteinase 3 (C-ANCA). Results: In clinically isolated syndrome group β2-Glycoprotein (IgM) and lupus anti-coagulant were positive in 1.3% of patients whereas ANA was positive in 1.3% and anti-β2-Glycoprotein I (IgM) was positive in 2.5% of control group. No rheumatologic disease was found in objects with positive tests. Conclusion: This study shows no specific difference between two groups.
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