Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence and Antibiotic Resistance of Clostridioides (Clostridium Difficile) in Meat and Meat Products: A Systematic Review and Meta-Analysis



Esfandiari Z1 ; Shoaei P2 ; Vakili B3 ; Farajzadegan Z4 ; Tarrahi MJ5 ; Emami Z6 ; Fakhri Y7 ; Weese JS8 ; Mahmudiono T9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nutrition and Food Security Research Center, Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Community and Preventive Medicine Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Epidemiology Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, Iran
  7. 7. Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  8. 8. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
  9. 9. Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia

Source: Iranian Journal of Public Health Published:2023

Abstract

Background: Meat and meat products are introduced as one of the frequent sources of Clostridioides difficile. We aimed to determine the prevalence and antibiotic resistance of C. difficile isolates in meat and meat products using a systematic review and meta-analysis. Methods: A literature search was performed in the primary international and bibliographic databases such as MEDLINE (PubMed), Cochrane Library, Embase, Scopus, and Web of Science to achieve all articles related to the prevalence and antibiotic resistance rates from 2007 to 2022. Results: The 278 retrieved articles were reduced to 54 worldwide eligible studies after screening and matching inclusion/ exclusion criteria. C. difficile was examined in different types of samples and its resistance to 10 antibi-otics. The pooled prevalence of C. difficile was 3.4% in all samples. C. difficile pooled prevalence was detected in fish, poultry, and red meat groups with 6.9%, 5.2%, and 3.2%, respectively. Regarding antibiotic resistance, the highest pooled prevalence was for ciprofloxacin (86.6%), followed by clindamycin (42.6%) and erythromycin (34%). The lowest pooled prevalence was observed in metronidazole (7.6%), vancomycin (6.6%), and chloram-phenicol (6%). Conclusion: Low resistance was found to commonly used drugs for C. difficile infection (CDI) treatment. Since each antibiotic can be predisposing cause for CDI development, this finding possibly will be warning from a One Health viewpoint about the misuse of antibiotics in the chain of farm to fork including agriculture, animal husbandry and the food industry and also their injudicious use in medicine. © 2023 Esfandiari et al. Published by Tehran University of Medical Sciences.
Related Docs
View other Related Docs
1. Clostridioides Difficile in Non-Hospital Sources (Animals, Food, and Environment) in Asian Countries: A Literature Review, Jundishapur Journal of Microbiology (2021)
2. Prevalence and Characterization of Clostridium Difficile in Beef and Mutton Meats of Isfahan Region, Iran, Jundishapur Journal of Microbiology (2014)
3. Examining the Extent of Contamination, Antibiotic Resistance, and Genetic Diversity of Clostridioides (Clostridium) Difficile Strains in Meat and Feces of Some Native Birds of Iran, BioMed Research International (2023)
4. Prevalence of Clostridium Difficile in Raw Beef, Cow, Sheep, Goat, Camel and Buffalo Meat in Iran, BMC Public Health (2014)
5. Prevalence, Antibiotic Resistance, and Genetic Diversities of Clostridium Difficile in Meat Nuggets From Various Sources in Isfahan, Iran, Journal of Food Quality (2022)
6. Molecular Study of Clostridium Difficile Isolated From Beef in Isfahan, Iran, Journal of Veterinary Research (2016)
7. A Review on Epidemiology of Clostridium Difficile Infection, Tehran University Medical Journal (2016)
8. Examination of the Prevalence, Genetic Diversity and Antibiotic Resistance of Clostridium Difficile (Clostridioides Difficile) in Semi-Cooked Ready-To-Eat Products in the Sale Centers of Isfahan Province, Iran, Journal of Health System Research (2024)
Experts (# of related papers)
View all Related Experts
Zahra Esfandiari (11)
Behrooz Ataei (10)
Other Related Docs
9. Isolation and Characterization of Clostridium Difficile in Farm Animals From Slaughterhouse to Retail Stage in Isfahan, Iran, Foodborne Pathogens and Disease (2015)
10. Clostridium Difficile Infection in an Iranian Hospital, BMC Research Notes (2012)
11. Molecular Epidemiology of Clostridium Difficile Infection in Iranian Hospitals, Antimicrobial Resistance and Infection Control (2019)
12. Molecular Characterization of Nosocomial Clostridium Difficile Infection in Pediatric Ward in Iran, SpringerPlus (2015)
13. Burden of Clostridium Clostridioides Difficile Infection Among Patients in Western Asia: A Systematic Review and Meta-Analysis, Iranian Journal of Public Health (2019)
14. The Relative Frequency of Clostridium Difficile in Fecal Samples of Hospitalized Patients With Diarrhea by Elisa Method, Journal of Isfahan Medical School (2012)
15. Investigating the Antagonistic Effect of Indigenous Probiotics on Carbapenem-Resistant Pseudomonas Aeruginosa Strains, BioMed Research International (2023)
16. Determination of Antibiotic Consumption Index for Animal Originated Foods Produced in Animal Husbandry in Iran, 2010, Journal of Environmental Health Science and Engineering (2014)
17. The Frequency of Methicillin-Resistant Staphylococcus Aureus Strains Isolated From Patients of a Teaching Hospital in Isfahan City, Iran, Journal of Isfahan Medical School (2021)
18. Investigation of Antibiotic Resistance Pattern and Detection of Methicillin- Resistant Strains (Mrsa) in Staphylococcus Aureus Isolates Associated With Bovine Mastitis, Journal of Isfahan Medical School (2014)
19. Frequency and Antibiotic Resistance Pattern of Salmonella Spp. Isolated From Traditional Dairies and Raw Milks Collected in Yazd Province, Iran, Iranian Journal of Microbiology (2024)
20. Clostridium Difficile Infection in Cancer Patients With Hospital Acquired Diarrhea at the Teaching Hospitals in Iran: Multilocus Sequence Typing Analysis (Mlst) and Antimicrobial Resistance Pattern, Annali di Igiene Medicina Preventiva e di Comunita (2019)
21. The Effect of Residual Antibiotics in Food on Intestinal Microbiota: A Systematic Review, Frontiers in Sustainable Food Systems (2023)
22. Systematic Review of Antibacterial Activity of Eravacycline: A Novel Fluorocycline Against Clinically Obtained Gram-Negative Bacteria, Reviews and Research in Medical Microbiology (2020)
23. Gut Microbiota in Burned Patients With Clostridioides Difficile Infection, Burns (2022)
24. Molecular Epidemiology of Colistin-Resistant Pseudomonas Aeruginosa Producing Ndm-1 From Hospitalized Patients in Iran, Iranian Journal of Basic Medical Sciences (2019)
25. Screening, Molecular Identification, Population Diversity, and Antibiotic Susceptibility Pattern of Actinomycetes Species Isolated From Meat and Meat Products of Slaughterhouses, Restaurants, and Meat Stores of a Developing Country, Iran, Frontiers in Microbiology (2023)
26. Widespread Antibiotic Resistance of Diarrheagenic Escherichia Coli and Shigella Species, Journal of Research in Medical Sciences (2014)
27. The Rate and Importance of Clostridium Difficile in Colorectal Cancer Patients, Gastroenterology and Hepatology from Bed to Bench (2019)
28. The Increasing Antimicrobial Resistance of Shigella Species Among Iranian Pediatrics: A Systematic Review and Meta-Analysis, Pathogens and Global Health (2023)
29. Clostridium Difficile Isolated From Faecal Samples in Patients With Ulcerative Colitis, BMC Infectious Diseases (2019)
30. Phenotypic and Genotypic Characteristics of Clostridium Difficile Isolates in Patients With Type 2 Diabetes in Iran, Infection and Drug Resistance (2020)
31. Resistance to Antibiotics and Biocides and Prevalence of Qacab, Smr and Nora Genes in Vancomycin-Resistant Enterococci Isolated From Patients of Medical Education Centers in Isfahan, Iran, Journal of Isfahan Medical School (2023)
32. Resistance of Shigella Strains to Extended-Spectrum Cephalosporins in Isfahan Province, Medical Journal of the Islamic Republic of Iran (2016)
33. Species Variety, Antibiotic Susceptibility Patterns and Prevalence of Enterotoxin Genes in Staphylococci Isolated From Foodstuff in Central Iran, Iranian Journal of Public Health (2020)
34. Frequency and Antibiotic Resistance of Hybrid Entroaggregative/Uropathogenic Escherichia Coli Isolated From Patients Hospitalized in Isfahan, Iran, Infection, Epidemiology and Microbiology (2021)
35. Evaluation of the Synergistic Effect of Tomatidine With Several Antibiotics Against Standard and Clinical Isolates of Staphylococcus Aureus, Enterococcus Faecalis, Pseudomonas Aeruginosa and Escherichia Coli, Iranian Journal of Pharmaceutical Research (2017)
36. Study on Prevalence, Antibiotic Susceptibility, and Tuf Gene Sequence-Based Genotyping of Species-Level of Coagulase-Negative Staphylococcus Isolated From Keratitis Caused by Using Soft Contact Lenses, Eye and Contact Lens (2016)
37. Antimicrobial Potential of Probiotic Strains From Bulgarian Cheese and Shallot Yogurt Against Staphylococcus Saprophyticus, BioMed research international (2024)
38. Evaluation of Virulence Factors, Antibiotic Resistance, and Biofilm Formation of Escherichia Coli Isolated From Milk and Dairy Products in Isfahan, Iran, Foods (2022)
39. Prevalence of Listeria Species in Food Products in Isfahan, Iran, International Journal of Food Microbiology (2008)
40. Prevalence and Risk Factors of Clostridium Difficile-Associated Diarrhea in Iranian Hospitalized Patients, Annals of Tropical Medicine and Public Health (2013)
41. Antimicrobial Activity of a Uv-Stable Bacteriocin-Like Inhibitory Substance (Blis) Produced by Enterococcus Faecium Strain Dsh20 Against Vancomycin-Resistant Enterococcus (Vre) Strains, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (2014)
42. Detection of Macrolid, Lincosamide and Streptogramin Resistance Genes in Methicillin-Resistant Staphylococcus Epidermidis Strains Isolated From Clinical Samples in Isfahan City, Iran, Journal of Isfahan Medical School (2017)