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The Effect of Intrathecal Administration of the Neuronal N-Type Calcium Channels Antagonist, Ω-Conotoxin Mviia, on Attenuating the Spontaneous and Naloxone-Precipitated Morphine Withdrawal in Rats Publisher



Bozorgi H1 ; Jahaniannajafabadi A2 ; Rabbani M1
Authors
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Authors Affiliations
  1. 1. Department of Toxicology and Pharmacology, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Toxin Reviews Published:2016


Abstract

The effect of ω-conotoxin MVIIA (Ziconotide or SNX-111) as an inhibitor of the neuronal N-type calcium channels on the signs of morphine withdrawal was investigated. The animals were rendered to physical dependence by the continuous intraperitoneal (IP) injections of gradually enhancing the doses of morphine (10–50 mg/kg) during 7 days. The withdrawal was induced in animals through the IP administration of naloxone with the dose of 2 mg/kg or it was elicited spontaneously. The single and chronic intrathecal injections of ω-conotoxin following the naloxone-precipitated withdrawal diminished the number of jumpings (p < 0.05). Moreover, both acute and chronic administrations of the drug alleviated the intensity of ptosis, piloerection, teeth chattering, diarrhea, irritability and genital grooming (p < 0.01) during the two models of the experiment. It can be concluded that the class of N-type calcium channel blockers ameliorate the severity of morphine withdrawal syndrome. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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