Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators

Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators

Mohammadpour M¹ ; Sadeghi A¹ ; Fassihi A¹ ; Saghaei L¹ ; Movahedian A² ; Rostami M¹

Show Affiliations

1. Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Biochemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Research in Pharmaceutical Sciences Published:2012

Abstract

A series of ortho-hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. N1-H hydroxypyridinones Va, Vb, and Ve were the best radical scavengers in DPPH free radical scavenging assay. Compound Vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. All of the synthesized compounds had very close chelating ability, compounds containing N1-CH3 hydroxypyridinone ring were stronger chelating agents.

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Style	Citing Format
MLA	Mohammadpour M, et al.. "Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators." Research in Pharmaceutical Sciences, vol. 7, no. 3, 2012, pp. 171-179.
APA	Mohammadpour M, Sadeghi A, Fassihi A, Saghaei L, Movahedian A, Rostami M (2012). Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators. Research in Pharmaceutical Sciences, 7(3), 171-179.
Chicago	Mohammadpour M, Sadeghi A, Fassihi A, Saghaei L, Movahedian A, Rostami M. "Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators." Research in Pharmaceutical Sciences 7, no. 3 (2012): 171-179.
Harvard	Mohammadpour M et al. (2012) 'Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators', Research in Pharmaceutical Sciences, 7(3), pp. 171-179.
Vancouver	Mohammadpour M, Sadeghi A, Fassihi A, Saghaei L, Movahedian A, Rostami M. Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators. Research in Pharmaceutical Sciences. 2012;7(3):171-179.
BibTex	@article{ author = {Mohammadpour M and Sadeghi A and Fassihi A and Saghaei L and Movahedian A and Rostami M}, title = {Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators}, journal = {Research in Pharmaceutical Sciences}, volume = {7}, number = {3}, pages = {171-179}, year = {2012} }
RIS	TY - JOUR AU - Mohammadpour M AU - Sadeghi A AU - Fassihi A AU - Saghaei L AU - Movahedian A AU - Rostami M TI - Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators JO - Research in Pharmaceutical Sciences VL - 7 IS - 3 SP - 171 EP - 179 PY - 2012 ER -

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