Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical

Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical Publisher

Jalilian AR¹ ; Sadeghi H² ; Zandi H³ ; Rowshanfarzad P¹ ; Shafaii K¹ ; Kamalidehghan M¹ ; Garousi J¹ ; Majdabadi A¹ ; Tavakoli MB²

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1. Nuclear Medicine Research Group, Agricultural Medical and Industrial Research School (AMIRS), Karaj, P.O.Box: 31485-498, Iran
2. Department of Biomedical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3. Islamic Azad University, Science and Research Unit, Tehran, P.O. Box: 14155-775, Iran

Source: Scientia Pharmaceutica Published:2008

Abstract

[ 61Cu]-N-(2-hydroxyacetophenone)glycinate ([ 61Cu] NHAG) was prepared using in house-made NHAG ligand and [61Cu]CuCI 2 produced via the natZn(p, x) 61Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [ 61Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [ 61Cu]NHAG was administered into normal and tumor bearing mice followed by bio distribution studies up to 180 minutes. The best tumor accumulation was observed by animal sacrification after 120 min (tumor/muscle and tumor/blood ratios were 25.6 and 3.4 respectively). [ 61Cu]NHAG is a potential PET radiotracer for tumor imaging.

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Style	Citing Format
MLA	Jalilian AR, et al.. "Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical." Scientia Pharmaceutica, vol. 76, no. 4, 2008, pp. 637-651.
APA	Jalilian AR, Sadeghi H, Zandi H, Rowshanfarzad P, Shafaii K, Kamalidehghan M, Garousi J, Majdabadi A, Tavakoli MB (2008). Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical. Scientia Pharmaceutica, 76(4), 637-651.
Chicago	Jalilian AR, Sadeghi H, Zandi H, Rowshanfarzad P, Shafaii K, Kamalidehghan M, Garousi J, Majdabadi A, Tavakoli MB. "Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical." Scientia Pharmaceutica 76, no. 4 (2008): 637-651.
Harvard	Jalilian AR et al. (2008) 'Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical', Scientia Pharmaceutica, 76(4), pp. 637-651.
Vancouver	Jalilian AR, Sadeghi H, Zandi H, Rowshanfarzad P, Shafaii K, Kamalidehghan M, et al.. Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical. Scientia Pharmaceutica. 2008;76(4):637-651.
BibTex	@article{ author = {Jalilian AR and Sadeghi H and Zandi H and Rowshanfarzad P and Shafaii K and Kamalidehghan M and Garousi J and Majdabadi A and Tavakoli MB}, title = {Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical}, journal = {Scientia Pharmaceutica}, volume = {76}, number = {4}, pages = {637-651}, year = {2008} }
RIS	TY - JOUR AU - Jalilian AR AU - Sadeghi H AU - Zandi H AU - Rowshanfarzad P AU - Shafaii K AU - Kamalidehghan M AU - Garousi J AU - Majdabadi A AU - Tavakoli MB TI - Synthesis and Preclinical Studies of [ 61Cu]-N-(2- Hydroxyacetophenone)Glycinate As a Possible Pet Radiopharmaceutical JO - Scientia Pharmaceutica VL - 76 IS - 4 SP - 637 EP - 651 PY - 2008 ER -

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