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Non Invasive Ventilation's Effectiveness (Niv) in Patients With Interstitial Lung Disease and Hypercapnic Respiratory Failure



Soltaninejad F1 ; Samim A2 ; Salmasi M2 ; Schobel C3 ; Penzel T4 ; Feizi A5 ; Amra B1
Authors
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Authors Affiliations
  1. 1. Bamdad Respiratory and Sleep Research Center, Department of Internal Medicine, Pulmonary Ward, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Pulmonary Ward, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. University of Duisburg-Essen, Center for Sleep Medicine, Ruhrland Hospital, University Hospital Essen, Essen, 45239, Germany
  4. 4. Center of Sleep Medicine, Charite-Universitatsmedizin Berlin, Berlin, Germany
  5. 5. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Tanaffos Published:2022

Abstract

Background: The therapeutic options for patients with interstitial lung disease (ILD) are limited. On the other hand, the role of noninvasive ventilation (NIV) in ILD management is not clear. This study investigated the effect of nighttime NIV in hypercapnic ILD patients. Materials and Methods: In this unblinded randomized clinical trial, we included a total of 20 ILD patients admitted in a specialized center with hypoxia, PaCO2>45, and HCO3>27. Participants were randomly allocated into two groups; intervention (nighttime NIV plus standard treatment) and control (standard treatment). The severity of dyspnea and the quality of life (QoL) was evaluated at beginning of the trial and after 30 days through Modified medical research council (mMRC) dyspnea scale and the SF-36 health survey questionnaire. Paired or Wilcoxon Signed rank tests and independent samples t-test or Mann-Whiney U test were used for between and within groups analyses, respectively. Results: The mean age of 20 patients enrolled was 62.57±6.67 and 40% were male. Although, a clinical significant improvement of dyspnea was detected in NIV group (P=0.046) after intervention, it was not statistically different from control group. Significant improvement was observed in physical functioning (P<0.001), social functioning (P=0.004) and pain (P=0.003) detected after 30 days in NIV group and the observed improvement in QoL was significantly higher than control group for physical functioning (P=0.042) and general health (0.049). Conclusion: Our results suggest NIV treatment in patients with ILD and hypercapnic respiratory failure could be advised in order to improve physical functioning. © 2022 NRITLD.
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