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The Safety of Diclofenac for the Management and Treatment of Actinic Keratoses Publisher Pubmed



Iraji F1 ; Siadat AH1 ; Asilian A1 ; Enshaieh S1 ; Shahmoradi Z1
Authors
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Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, AlZahra Hospital, Dermatology Department, Isfahan, Iran

Source: Expert Opinion on Drug Safety Published:2008


Abstract

Background: Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies. Objective: Is diclofenac safe and effective for the management and treatment of AKs? Method: All the papers that were cited in Medline and ISI Web of Science are included in this study. Results/conclusion: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs. © 2008 Informa UK Ltd.
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