Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables

Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables Publisher Pubmed

Maracy M^{1, 2} ; Dunn G¹

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1. Biostatistics, Health Methodology Research Group, School of Community Based Medicine, University of Manchester, United Kingdom
2. Biostatistics and Epidemiology Group, School of Health, Isfahan University of Medical Science, Iran

Source: Statistical Methods in Medical Research Published:2011

Abstract

We present a relatively non-technical and practically orientated review of statistical methods that can be used to estimate dose-response relationships in randomised controlled psychotherapy trials in which participants fail to attend all of the planned sessions of therapy. Here we are investigating the effects on treatment outcome of the number of sessions attended when the latter is possibly subject to hidden selection effects (hidden confounding). The aim is to estimate the parameters of a structural mean model (SMM) using randomisation, and possibly randomisation by covariate interactions, as instrumental variables. We describe, compare and illustrate the equivalence of the use of a simple G-estimation algorithm and two two-stage least squares procedures that are traditionally used in economics. © The Author(s), 2011.

Style	Citing Format
MLA	Maracy M, Dunn G. "Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables." Statistical Methods in Medical Research, vol. 20, no. 3, 2011, pp. 191-215.
APA	Maracy M, Dunn G (2011). Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables. Statistical Methods in Medical Research, 20(3), 191-215.
Chicago	Maracy M, Dunn G. "Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables." Statistical Methods in Medical Research 20, no. 3 (2011): 191-215.
Harvard	Maracy M, Dunn G (2011) 'Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables', Statistical Methods in Medical Research, 20(3), pp. 191-215.
Vancouver	Maracy M, Dunn G. Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables. Statistical Methods in Medical Research. 2011;20(3):191-215.
BibTex	@article{ author = {Maracy M and Dunn G}, title = {Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables}, journal = {Statistical Methods in Medical Research}, volume = {20}, number = {3}, pages = {191-215}, year = {2011} }
RIS	TY - JOUR AU - Maracy M AU - Dunn G TI - Estimating Dose-Response Effects in Psychological Treatment Trials: The Role of Instrumental Variables JO - Statistical Methods in Medical Research VL - 20 IS - 3 SP - 191 EP - 215 PY - 2011 ER -

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