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Value of Coronary Artery Calcium Scoring in Iranian Patients Suspected to Coronary Artery Disease Pubmed



Parsa AFZ1 ; Larimi NG1 ; Motevali M2 ; Gholipour AM3 ; Shahreza MR3 ; Ranjpoor F4 ; Dashti MM5
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Imaging, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Gheytarieh Clinic, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Community Medicine, Yariresan Parsian, LTD, Tehran, Iran
  5. 5. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Acta Medica Iranica Published:2015


Abstract

Coronary artery calcium scoring (CACS) is a reasonable test for patients with the possibility of atherosclerosis. It can also be used for reclassifying the coronary artery disease (CAD) to the high-risk status by higher CACS and subsequently modifying the management of the patients.The purpose of this study was to investigate the association of CACS to the severity of coronary artery disease in the patients who were scheduled to perform coronary artery angiography (CAG) by tradition. CACS could be a simple, relatively cost-benefit, and noninvasive method for early screening of patients with obstructive coronary artery disease. Method: In the present study, CAC scoring was evaluated by non-enhanced Multi-Detector Computed Tomography (MDCT) in a total 239 patient suffering from coronary artery disease. Of them, 223 patients were planned to undergo CAG based on clinical examination or other noninvasive diagnostic methods (such as MPI, ETT, EKG or Echo). Results: Our results showed that 11 of 67 patients with a negative CACS (zero) had obstructive coronary artery disease derived from the results of CAG. We also found a significant correlation between high CACS (more than 400) and extensive obstructive CAD, except for the two patients who had only mild CAD. There was a linear correlation between CACS and the severity of CAD on the basis of Gensini score and the number of involved arteries (CC=0.507, PV<0.001). Despite fairly high sensitivity (86.6) of zero CAC among patients with a negative score (86%), zero CACS cannot rule out the existence of obstructive coronary artery disease. As we found, increased level of CACS (>400) might be a significant indicative of CAD in referring patients. © 2015 Tehran University of Medical Sciences. All rights reserved.
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