Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
T-Cell Abnormalities in Common Variable Immunodeficiency Publisher Pubmed



Azizi G1, 2, 3 ; Rezaei N2, 4, 5 ; Kiaee F2, 3 ; Tavakolinia N2, 3 ; Yazdani R6 ; Mirshafiey A7 ; Aghamohammadi A2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Investigational Allergology and Clinical Immunology Published:2016


Abstract

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. © 2016 Esmon Publicidad.
Related Docs
View other Related Docs
1. Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management, Expert Review of Clinical Immunology (2017)
2. Abnormality of Regulatory T Cells in Common Variable Immunodeficiency, Cellular Immunology (2017)
3. Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed As Common Variable Immunodeficiency, International Reviews of Immunology (2016)
4. Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients, Expert Review of Clinical Immunology (2014)
5. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
6. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
7. Noninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2024)
8. Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?, Allergologia et Immunopathologia (2017)
Experts (# of related papers)
View all Related Experts
Mazdak Ganjalikhani Hakemi (15)
Abbas Rezaei (6)
Other Related Docs
9. Important Factors Influencing Severity of Common Variable Immunodeficiency, Archives of Iranian Medicine (2016)
10. Comparison of Various Classifications for Patients With Common Variable Immunodeficiency (Cvid) Using Measurement of B-Cell Subsets, Allergologia et Immunopathologia (2017)
11. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)
12. A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2017)
13. Role of Apoptosis in the Pathogenesis of Common Variable Immunodeficiency (Cvid), Endocrine, Metabolic and Immune Disorders - Drug Targets (2017)
14. Comparison of the Percentage of Regulatory T Cells and Their P-Stat5 Expression in Allergic and Non-Allergic Common Variable Immunodeficiency Patients, Immunological Investigations (2019)
15. Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency, Clinical Immunology (2017)
16. Decreased Expression of B Cell Maturation Antigen in Patients With Common Variable Immunodeficiency, Pediatric, Allergy, Immunology, and Pulmonology (2017)
17. A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency, Endocrine, Metabolic and Immune Disorders - Drug Targets (2017)
18. Autoimmunity in Primary T-Cell Immunodeficiencies, Expert Review of Clinical Immunology (2016)
19. Evaluation of the T Helper 17 Cell Specific Genes and the Innate Lymphoid Cells Counts in the Peripheral Blood of Patients With the Common Variable Immunodeficiency, Journal of Research in Medical Sciences (2014)
20. The Use of Immunoglobulin Therapy in Primary Immunodeficiency Diseases, Endocrine, Metabolic and Immune Disorders - Drug Targets (2016)
21. Approach to the Management of Autoimmunity in Primary Immunodeficiency, Scandinavian Journal of Immunology (2017)
22. Comparison of Bone Mineral Density in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients, Endocrine, Metabolic and Immune Disorders - Drug Targets (2017)
23. Clinical, Immunologic, Molecular Analyses and Outcomes of Iranian Patients With Lrba Deficiency: A Longitudinal Study, Pediatric Allergy and Immunology (2017)
24. Assessment of the Expression Level of B-Cell Lymphoma 6 (Bcl6) in Peripheral Blood Cd38+ B Lymphocytes in Patients With Common Variable Immunodeficiency (Cvid), Journal of Isfahan Medical School (2017)
25. Monogenic Primary Immunodeficiency Disorder Associated With Common Variable Immunodeficiency and Autoimmunity, International Archives of Allergy and Immunology (2020)
26. Primary Antibody Deficiency in a Tertiary Referral Hospital: A 30-Year Experiment, Journal of Investigational Allergology and Clinical Immunology (2015)
27. Clinical Phenotype Classification for Selective Immunoglobulin a Deficiency, Expert Review of Clinical Immunology (2015)
28. Primary Immunodeficiency Disorders in Iran: Update and New Insights From the Third Report of the National Registry, Journal of Clinical Immunology (2014)
29. Evaluation of Il-17 Gene Expression in the Peripheral Blood of Patients With Common Variable Immunodeficiency, Journal of Isfahan Medical School (2013)
30. Clinical, Immunologic, and Genetic Spectrum of 696 Patients With Combined Immunodeficiency, Journal of Allergy and Clinical Immunology (2018)
31. Increased Irf4 Expression in Isolated B Cells From Common Variable Immunodeficiency (Cvid) Patients, Allergologia et Immunopathologia (2019)
32. Investigating the Frequency of the Peripheral Blood B and Transitional B Cells in the Patients With Common Variable Immunodeficiency, Journal of Isfahan Medical School (2016)
33. Gene Mutations Responsible for Primary Immunodeficiency Disorders: A Report From the First Primary Immunodeficiency Biobank in Iran, Allergy, Asthma and Clinical Immunology (2016)
34. Recurrent Vulvovaginal Candidiasis: Could It Be Related to Cell-Mediated Immunity Defect in Response to Candida Antigen?, International Journal of Fertility and Sterility (2017)
35. Clinical, Immunological, and Genetic Findings in Iranian Patients With Mhc-Ii Deficiency: Confirmation of C.162Delg Rfxank Founder Mutation in the Iranian Population, Journal of Clinical Immunology (2023)
36. Asthma and Allergic Diseases in a Selected Group of Patients With Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2016)
37. Evaluation of Mutation in B Cell Maturation Antigen (Bcma) Gene in Patients With Common Variable Immunodeficiency (Cvid), Journal of Isfahan Medical School (2016)
38. Immunodeficiencies Affecting Cellular and Humoral Immunity, Inborn Errors of Immunity: A Practical Guide (2021)
39. Selective Iga Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Scandinavian Journal of Immunology (2017)
40. Evaluation of Il-17 Gene Expression in Peripheral Blood and Sputum of Asthma Patients and Healthy Individuals, Tehran University Medical Journal (2014)
41. Frequency and Clinical Manifestations of Patients With Primary Immunodeficiency Disorders in Iran: Update From the Iranian Primary Immunodeficiency Registry, Journal of Clinical Immunology (2006)
42. Cernunnos Deficiency Associated With Bcg Adenitis and Autoimmunity: First Case From the National Iranian Registry and Review of the Literature, Clinical Immunology (2017)
43. Renal Amyloidosis in Common Variable Immunodeficiency, Nefrologia (2010)
44. Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders, Journal of Investigational Allergology and Clinical Immunology (2017)
45. Increased Expression of B Lymphocyte Induced Maturation Protein 1 (Blimp1) in Patients With Common Variable Immunodeficiency (Cvid), Iranian Journal of Allergy, Asthma and Immunology (2020)