T-Cell Abnormalities in Common Variable Immunodeficiency Publisher Pubmed



Azizi G^{1, 2, 3} ; Rezaei N^{2, 4, 5} ; Kiaee F^{2, 3} ; Tavakolinia N^{2, 3} ; Yazdani R⁶ ; Mirshafiey A⁷ ; Aghamohammadi A^{2, 3}
Source: Journal of Investigational Allergology and Clinical Immunology Published:2016

Abstract

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. © 2016 Esmon Publicidad.