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Changes in the Fev1/Fvc Ratio During Childhood and Adolescence: An Intercontinental Study Publisher Pubmed



Quanjer PH1 ; Stanojevic S4 ; Stocks J1 ; Hall GL7 ; Prasad KVV8 ; Cole TJ4 ; Rosenthal M6 ; Perezpadilla R9 ; Hankinson JL10 ; Falaschetti E5 ; Golshan M11 ; Brunekreef B2, 3 ; Alrawas O12 ; Kuhr J13 Show All Authors
Authors
  1. Quanjer PH1
  2. Stanojevic S4
  3. Stocks J1
  4. Hall GL7
  5. Prasad KVV8
  6. Cole TJ4
  7. Rosenthal M6
  8. Perezpadilla R9
  9. Hankinson JL10
  10. Falaschetti E5
  11. Golshan M11
  12. Brunekreef B2, 3
  13. Alrawas O12
  14. Kuhr J13
  15. Trabelsi Y14
  16. Ip MSM15
Show Affiliations
Authors Affiliations
  1. 1. Depts of Pulmonary Diseases and Paediatrics, Erasmus Medical Centre, Erasmus University, Rotterdam, Netherlands
  2. 2. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
  3. 3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
  4. 4. Medical Research Council Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom
  5. 5. Dept of Epidemiology and Public Health, University College London, London, United Kingdom
  6. 6. Royal Brompton Hospital, London, United Kingdom
  7. 7. Princess Margaret Hospital for Children, School of Paediatric and Child Health, University of Western Australia, Perth, WA, Australia
  8. 8. Government Vemana Yoga Research Institute, Ameerpet, India
  9. 9. National Institute of Respiratory Diseases, Mexico, Mexico
  10. 10. Hankinson Consulting, Valdosta, GA, United States
  11. 11. Dept of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Dept of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
  13. 13. Klinik fur Kinder- und Jugendmedizin, Zentrum fur Kinder und Frauen, Kinderklinik Stadtisches Klinikum Karlsruhe, Karlsruhe, Germany
  14. 14. Universite de Sousse, Laboratoire de Physiologie et des Explorations Fonctionnelles, Faculte de Medecine de Sousse, Sousse, Tunisia
  15. 15. Dept of Medicine, University of Hong Kong, Hong Kong, Pokfulam, Hong Kong

Source: European Respiratory Journal Published:2010


Abstract

In children, the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) is reportedly constant or falls linearly with age, whereas the ratio of residual volume (RV) to total lung capacity (TLC) remains constant. This seems counter-intuitive given the changes in airway properties, body proportions, thoracic shape and respiratory muscle function that occur during growth. The age dependence of lung volumes, FEV1/FVC and RV/TLC were studied in children worldwide. Spirometric data were available for 22,412 healthy youths (51.4% male) aged 4-20 yrs from 15 centres, and RV and TLC data for 2,253 youths (56.7% male) from four centres; three sets included sitting height (SH). Data were fitted as a function of age, height and SH. In childhood, FVC outgrows TLC and FEV1, leading to falls in FEV1/FVC and RV/TLC; these trends are reversed in adolescence. Taking into account SH materially reduces differences in pulmonary function within and between ethnic groups. The highest FEV1/FVC ratios occur in those shortest for their age. When interpreting lung function test results, the changing pattern in FEV1/FVC and RV/TLC should be considered. Prediction equations for children and adolescents should take into account sex, height, age, ethnic group, and, ideally, also SH. Copyright©ERS 2010.
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