Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague

Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats Publisher Pubmed

Hajimohammadi B¹ ; Eslami G¹ ; Zandi H¹ ; Ehrampoush MH¹ ; Naimi A² ; Derakhshan M² ; Hedayat P² ; Fallahi R³ ; Fallahzadeh H⁴ ; Rezvani ME⁵ ; Vakili M⁶ ; Moshtaghioun SM⁷ ; Athari SS⁸ ; Asadiyousefabad SL⁹ Show All Authors

Hajimohammadi B¹
Eslami G¹
Zandi H¹
Ehrampoush MH¹
Naimi A²
Derakhshan M²
Hedayat P²
Fallahi R³
Fallahzadeh H⁴
Rezvani ME⁵
Vakili M⁶
Moshtaghioun SM⁷
Athari SS⁸
Asadiyousefabad SL⁹
Hosseini SS¹
Shirdeli M¹⁰
Ahmadian S¹
Mortazavi S¹
Loni E¹
Ajamein V¹
Ahmadi A¹¹
Askari V¹

Show Affiliations

1. Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Iran
2. Department of Pathology, Medical University of Isfahan, Isfahan, Iran
3. Animal Viral Diseases Research Department, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, 3197619751, Iran
4. Department of Biostatistics and Epidemiology, Daneshjoo Boulevard, Health School, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blv., Yazd, 8916188638, Iran
5. Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Iran
6. Department of Community and Preventive Medicine, Health Monitoring Research Center, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blv., Yazd, 8916188638, Iran
7. Department of Biology, Faculty of Sciences, Yazd University, Yazd, Iran
8. Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
9. Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Iran
10. Department of Food Science and Technology, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
11. Department of Pathobiology, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran

Source: Scientific Reports Published:2021

Abstract

Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague–Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health. © 2021, The Author(s).

Experts (# of related papers)

Seyyed Morteza Safavi (1)

Style	Citing Format
MLA	Hajimohammadi B, et al.. "Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats." Scientific Reports, vol. 11, no. 1, 2021, pp. -.
APA	Hajimohammadi B, Eslami G, Zandi H, Ehrampoush MH, Naimi A, Derakhshan M, Hedayat P, Fallahi R, Fallahzadeh H, Rezvani ME, Vakili M, Moshtaghioun SM, Athari SS, Asadiyousefabad SL, Hosseini SS, Shirdeli M, Ahmadian S, Mortazavi S, Loni E, ... Askari V (2021). Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats. Scientific Reports, 11(1), -.
Chicago	Hajimohammadi B, Eslami G, Zandi H, Ehrampoush MH, Naimi A, Derakhshan M, Hedayat P, et al.. "Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats." Scientific Reports 11, no. 1 (2021): -.
Harvard	Hajimohammadi B et al. (2021) 'Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats', Scientific Reports, 11(1), pp. -.
Vancouver	Hajimohammadi B, Eslami G, Zandi H, Ehrampoush MH, Naimi A, Derakhshan M, et al.. Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats. Scientific Reports. 2021;11(1):-.
BibTex	@article{ author = {Hajimohammadi B and Eslami G and Zandi H and Ehrampoush MH and Naimi A and Derakhshan M and Hedayat P and Fallahi R and Fallahzadeh H and Rezvani ME and Vakili M and Moshtaghioun SM and Athari SS and Asadiyousefabad SL and Hosseini SS and Shirdeli M and Ahmadian S and Mortazavi S and Loni E and Ajamein V and Ahmadi A and Askari V}, title = {Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats}, journal = {Scientific Reports}, volume = {11}, number = {1}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Hajimohammadi B AU - Eslami G AU - Zandi H AU - Ehrampoush MH AU - Naimi A AU - Derakhshan M AU - Hedayat P AU - Fallahi R AU - Fallahzadeh H AU - Rezvani ME AU - Vakili M AU - Moshtaghioun SM AU - Athari SS AU - Asadiyousefabad SL AU - Hosseini SS AU - Shirdeli M AU - Ahmadian S AU - Mortazavi S AU - Loni E AU - Ajamein V AU - Ahmadi A AU - Askari V TI - Safety Assessment of Genetically Modified Rice Expressing Cry1ab Protein in Sprague–Dawley Rats JO - Scientific Reports VL - 11 IS - 1 SP - EP - PY - 2021 ER -

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